325,636
edits
LOG IN. UPLOAD PICTURES.
The Philippines has Zambo Mart to help propagate the Chavacano Language.
Difference between revisions of "Black Cohosh"
Jump to navigation
Jump to search
→ → Go back HOME to Zamboanga: the Portal to the Philippines.
→News About Black Cohosh
| Line 57: | Line 57: | ||
<center>{{herbheader}}</center> | <center>{{herbheader}}</center> | ||
==News About Black Cohosh== | ==News About Black Cohosh== | ||
'''Finding real relief''' | |||
*Source:http://scienceline.org/2016/04/finding-real-relief/ | |||
: By Kelsey R. Kennedy | |||
The search for an effective dietary supplement | |||
A walk down the supplement aisle of your local health food store can be daunting. There is an incredible array of choices, from the bottles claiming to boost your immune system to the capsules full of exotic herbs. Online, there are countless websites recommending dietary supplements to cure whatever ails you. And Americans are acting on these recommendations; the Food and Drug Administration (FDA) estimates they spent more than $36 billion on dietary supplements in 2014. | |||
But that walk down the supplements aisle is a little like a walk into the Wild West. Despite the claims and official-looking recommendations on those bottles, consumers have no guarantee that what they’re buying will do them any good. Supplement manufacturers face only relatively lax regulations from the FDA and aren’t required to prove that what they’re selling actually does anything. | |||
Congress defined dietary supplements, and the power the FDA has to regulate them, in 1994 with the Dietary Supplement Health and Education Act. Under the law, manufacturers can’t claim their product cures any disease and must prove the supplements were produced following a set of standards known as Good Manufacturing Practices. | |||
For dietary supplements that were on the market before 1994, the FDA just has to assume they’re safe. If an ingredient isn’t safe, the FDA must prove it is harmful before it can be taken off the market. Manufacturers aren’t required to standardize their products, so the amount of an active ingredient can vary from batch to batch. They also don’t have to prove their supplements are effective for treating any conditions. | |||
Navigating the supplement aisle may soon be easier and safer for consumers, thanks to academic researchers who are examining the safety and effectiveness of some of these dietary supplements. The National Institute of Health (NIH) launched its Botanical Research Centers Program in 1999 to fund supplement research. Their 2015 round of funding dedicates close to $35 million to labs across the country. | |||
One of these labs, the University of Illinois at Chicago’s Center for Botanical Dietary Supplements Research, has been funded by the NIH since the program started. They’re not looking for new plants to take to market. Instead, they’re looking at supplements already available on store shelves. “The market is primarily women,” says Richard van Breemen, the Center’s director. “They buy them for their families, they buy them for themselves.” | |||
Many women stopped hormone treatments for menopausal symptoms such as hot flashes after the NIH Women’s Health Initiative hormone therapy trials in the early 2000s found elevated risk of breast cancer and stroke. “Women started turning to alternatives like botanical dietary supplements,” says van Breemen. These supplements include red clover, hops, and black cohosh, a flower found in the Eastern U.S. Van Breemen’s team started looking at the safety of these botanical dietary supplements. “There’s concern that if you substitute one estrogen for another, you’ll have the same problems,” he says. | |||
To test the safety and effectiveness of black cohosh and red clover, van Breemen and his team take a stepwise approach. The team makes a standardized sample of a plant extract and then tests it in animals and humans. “We modeled these steps after how drugs are developed for human use,” says van Breemen. Their process is similar to how pharmaceutical companies prove to the FDA that a new drug is safe and effective. The results of their clinical trial were published in 2009. The hormone treatment prescribed by doctors proved most effective at relieving hot flashes in menopausal women, while red clover was nearly as effective as placebo. Black cohosh was only about half as effective as placebo. | |||
“Red clover does contain estrogenic compounds,” says van Breemen, so it was not surprising to find it had some kind of effect. But the black cohosh results suggest the herb is useless for relieving hot flashes. “We could not find an alternate mechanism for black cohosh, other than one that acts on the nervous system,” he says. Black cohosh contains serotonin-like molecules that could have an effect on the nervous system, but van Breemen found there was a key roadblock. Those molecules “won’t reach the blood-brain barrier, they won’t even reach the bloodstream,” he says. This means the molecules won’t be able to reach the brain, so they won’t have any chance to have an effect on the nervous system. | |||
While they couldn’t find any benefits for women from black cohosh, van Breemen’s lab was at least able to establish that it was safe. Concerns have been raised about black cohosh’s potential to cause liver damage, but van Breemen says liver enzyme tests done during the study were all normal. Black cohosh, he says, is “perhaps ineffective for controlling hot flashes, but nevertheless safe.” For van Breemen and his team, safety is paramount. “Ultimately, we want to have a product that is safe, and hopefully effective as well.” | |||
The NIH has also awarded funding to a new research center at the Icahn School of Medicine at Mount Sinai in New York. Led by Giulio Pasinetti and Richard Dixon, the new center will focus on how certain dietary supplements can help alleviate stress-induced depression and mood disorders. The team has already identified several compounds, called polyphenols, found in grapes and grape seeds that help the brain better handle stress. With the NIH funding, they will try to determine exactly how these compounds work in the body. | |||
They will also look at the role bacteria and fungi in the microbiome, especially in the gut, may play in making these compounds available for the body to use. Gut bacteria break down what we eat into metabolites, which are compounds formed during bacterial metabolism. “We are characterizing all of the microbiome that would influence the generation of these metabolites,” says Pasinetti. He hopes this work will lead to a probiotic composed of specific bacteria that help make more polyphenols available for the body to use. Pasinetti is very optimistic about the potential for a combination approach with probiotics and polyphenols. “I think in the framework of the program, over the next five years, we may have a new treatment for major depression.” | |||
Louisiana State University’s Botanical Dietary Supplements Research Center received NIH funds as well, to continue their work with botanical supplements for the prevention and treatment of obesity and diabetes. The center, established in 2005, has discovered several plant products, like a byproduct of sugarcane processing and a type of red lettuce, that may be effective for controlling glucose levels. The center is in the early stages of clinical trials to establish the safety of Russian tarragon for treatment of pre-diabetes. | |||
“We hope this research will advance scientific understanding that will lead to better design of future clinical studies and better-informed decisions by consumers,” says Barbara Sorkin, director of the NIH Centers for Advancing Research on Botanicals and Other Natural Products Program. Sorkin says determining how botanical products work in the human body helps researchers design better clinical trials to test supplements. While the NIH funds research on the effectiveness of dietary supplements, the findings generated by research centers may not make any difference in terms of policy. | |||
While policies may not change, Richard van Breemen hopes his research will at least pressure commercial supplement producers to use clinical trials to test the safety and effectiveness of their products. “I think there’s a place for dietary supplements for many generations to come,” says van Breemen. “But we need to understand how they work and how to make them safe and effective.” | |||
---- | |||
'''5 ways to keep cool when you’re having a hot flush''' | '''5 ways to keep cool when you’re having a hot flush''' | ||
*Source:http://home.bt.com/lifestyle/health/health-concerns/5-ways-to-keep-cool-when-youre-having-a-hot-flush-11364096741302 | *Source:http://home.bt.com/lifestyle/health/health-concerns/5-ways-to-keep-cool-when-youre-having-a-hot-flush-11364096741302 | ||