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==News About Yohimbe == | ==News About Yohimbe == | ||
'''UCLA Study Finds Properties of Yohimbe Tree Bark Hold Promise for Revolutionizing Treatment of Anxiety Disorders''' | |||
*Source:http://newsroom.ucla.edu/releases/UCLA-Study-Finds-Properties-of-5062 | |||
:By Dan Page | |||
New findings at the UCLANeuropsychiatric Institute demonstrate the potential of a substance found inyohimbe tree bark to accelerate recovery from anxiety disorders suffered bymillions of Americans. | |||
In the latest in a series ofstudies of how mice acquire, express and extinguish conditioned fear, the UCLAteam finds yohimbine helps mice learn to overcome the fear faster by enhancingthe effects of the natural release of adrenaline. Adrenaline promptsphysiological changes such as increased heart and metabolism rates in responseto physical and mental stress. | |||
Writing in the March/April editionof the peer-reviewed journal Learning and Memory, the team reported that micetreated with yohimbine overcame their fear four times as fast as those treatedwith vehicle or propanolol, a medication commonly used to treat symptoms ofanxiety disorders by blunting the physiological effects of adrenaline. | |||
Yohimbine is most commonly used to treat erectiledysfunction. It can cause anxiety in susceptible persons, and should never beused without a doctor's recommendation and supervision. | |||
These new findings come on theheels of evidence published by the same UCLA research team last fall (Journalof Experimental Psychology, October 2003) that suggests full, frequent exposureto a fear during behavioral therapy may be more effective in treating anxietythan the standard practice of gradual, spaced exposure. For example, it may bemore effective to treat fear of heights by taking a patient straight to the topof a tall building in rapid succession, rather then taking them to increasinglyhigher floors over a lengthy period of time. | |||
"We are at the threshold of a newera in our understanding and treatment ofanxiety disorders," said Dr. Mark Barad, the UCLA Neuropsychiatric Institute'sTennenbaum Family Center faculty scholar and an assistant professor ofpsychiatry and biobehavioral sciences. "Current treatment protocols usemedications intended to blunt the physiological effects of fear and usebehavioral therapy designed to space exposure to the fear stimulus over time.Our findings show treatment may be more effective if we do exactly theopposite. | |||
Anxiety disorders affect about 19million Americans per year, consuming about one-third of total U.S. mentalhealth costs of $148 billion in 1990. They include obsessive-compulsivedisorder, panic disorder, social phobia, post-traumatic stress disorder,generalized anxiety disorder and specific phobias. Although these diseases aregenerally not deadly, they take an enormous toll in morbidity. Sufferersconstantly avoid fearful circumstances and pay an enormous price in socialisolation, poor job performance and advancement, and time wasted on worries andfears. | |||
Both acquiring and overcoming, orextinguishing, conditional fear are forms of active learning. A unique pairingof an initially neutral conditional stimulus with an unpleasant unconditionalstimulus is needed to acquire a conditional fear. In both UCLA studies, theconditional stimulus was a tone and the unconditional stimulus was a mild footshock. | |||
Although extinction, the reductionof conditional responding after repeated exposures to the conditional stimulusalone, might initially appear to be a passive decay or erasure of thisassociation, many studies indicate that extinction is new inhibitory learning,which leaves the original memory intact. | |||
:The National Institute of MentalHealth is funding the research. | |||
Other UCLA investigators involvedin the ongoing research are Chris Cain and Ashley Blouin of the UCLA InterdepartmentalProgram in Neuroscience. Barad also is affiliated with the UCLA Brain ResearchInstitute. | |||
The Tennenbaum Family Center atthe UCLA Neuropsychiatric Institute encourages research into brain plasticityby supporting the work of a faculty scholar, providing seed money to promisingresearch projects and offering graduate student and post-doctoral fellowshipsupport. | |||
The UCLA NeuropsychiatricInstitute is an interdisciplinary research and education institute devoted tothe understanding of complex human behavior, including the genetic, biological,behavioral and sociocultural underpinnings of normal behavior, and the causesand consequences of neuropsychiatric disorders. Information about the instituteis available online at www.npi.ucla.edu. | |||
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'''Bark From Yohimbe Tree Has Potential To Treat Anxiety Disorders''' | '''Bark From Yohimbe Tree Has Potential To Treat Anxiety Disorders''' | ||
*Source:http://www.scienceagogo.com/news/20040304203135data_trunc_sys.shtml | *Source:http://www.scienceagogo.com/news/20040304203135data_trunc_sys.shtml | ||