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Herbal Remedies and Medicinal Cures for Diseases, Ailments & Illnesses that afflict Humans and Animals
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accept the bitter to get better

Grape Fruits

Dietary supplement is a product that contains vitamins, minerals, herbs or other botanicals, amino acids, enzymes, and/or other ingredients intended to supplement the diet. The U.S. Food and Drug Administration has special labeling requirements for dietary supplements and treats them as foods, not drugs.

Manufacturers and distributors of dietary supplements and dietary ingredients are prohibited from marketing products that are adulterated or misbranded. That means that these firms are responsible for evaluating the safety and labeling of their products before marketing to ensure that they meet all the requirements of DSHEA and FDA regulations.

Wars of ancient history were about possessions, territory, power, control, family, betrayal, lover's quarrel, politics and sometimes religion.

But we are in the Modern era and supposedly more educated and enlightened .

Think about this. Don't just brush off these questions.

Why is RELIGION still involved in WARS? Isn't religion supposed to be about PEACE?
Ask yourself; What religion always campaign to have its religious laws be accepted as government laws, always involved in wars and consistently causing WARS, yet insists that it's a religion of peace?

WHY??

There are only two kinds of people who teach tolerance:

The Bullies. They want you to tolerate them so they can continue to maliciously deprive you. Do not believe these bullies teaching tolerance, saying that it’s the path to prevent hatred and prejudice.
The victims who are waiting for the right moment to retaliate. They can’t win yet, so they tolerate.

Grape Seed

The medicinal herb Grape Seed Extract as an alternative herbal remedy - The grape seeds used to produce this extract are generally obtained from wine manufacturers.

What Grape seed extract Is Used For

Grape seed extract is used as an herbal remedy for conditions related to the heart and blood vessels, such as atherosclerosis (hardening of the arteries), high blood pressure, high cholesterol, and poor circulation.
Other reasons for the use of grape seed extract include complications related to diabetes, such as nerve and eye damage; vision problems, such as macular degeneration (which can cause blindness); and swelling after an injury or surgery.
Grape seed extract is also used for cancer prevention and wound healing.

How Grape seed extract Is Used

Grape seed extract is prepared from the seed of grapes. It is available in capsule and tablet forms.

What the Science Says about Grape seed extract

Laboratory studies have shown that grape seed contains antioxidants-substances that prevent cell damage caused by free radicals, which are highly reactive molecules that can damage cell function. However, it is still unclear how grape seed might affect human health.
Grape seed extracts have shown some beneficial antioxidant effects in preliminary clinical trials. However, few trials have looked at specific diseases or conditions, and little scientific evidence is available.
A study funded by the National Cancer Institute (NCI) found that grape seed extract did not reduce the hardening of breast tissue that can occur after radiation therapy for breast cancer.
NCI is also funding studies evaluating whether grape seed extract is effective in preventing breast and prostate cancers.
NCCAM is studying whether the action of grape seed extract and its components may benefit the heart or have protective effects in the brain.

Side Effects and Cautions of Grape seed extract

Grape seed extract is generally well tolerated when taken by mouth. It has been used safely for up to 8 weeks in clinical trials.
Side effects that have been reported most often include headache; a dry, itchy scalp; dizziness; and nausea.
The interactions between grape seed extract and medicines or other supplements have not been carefully studied.
Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

News About Grape Seed

Grapeseed Oil May Reduce Heart Disease, Diabetes Risks

Source:http://www.techtimes.com/articles/139405/20160309/grapeseed-oil-may-reduce-heart-disease-diabetes-risks.htm

By Katherine Derla Tech Times

Grape seed extract is an industrial derivative of grape seeds, extremely rich in antioxidants and oligomeric proanthocyanidin complexes (OPCs).

The extract has been linked to a wide range of possible therapeutic properties including healing wounds and treating conditions such as high cholesterol, atherosclerosis, macular degeneration, poor circulation, nerve damage, as well as preventing cancer.

Although many of these health claims are still not completely backed up by "high quality" studies, strong evidence is beginning to emerge on grape seed extract's extensive health benefits.

Grape seed extract is available as a dietary supplement in either a liquid form, tablets or capsules. Supplements generally contain between 50 to 100 mg of the extract.

This Medical News Today information article provides details on the benefits of grape seed extract as well as side effects and precautions associated with its use.

What are the benefits of grape seed extract

Studies on animal models have revealed that the extract can be effective in treating heart diseases. Some experts think that grape seed extract could even have anticancer and cancer chemopreventive potential.

Over recent years there has been a great deal of research pointing to key therapeutic properties of the grape seed extract. Listed below are some of the key findings.

Health benefits associated with grape seed extract:

•Healing wounds - Grape seed extract can heal dermal wounds.

A study, published in the journal Free Radical Biology and Medicine, "provided firm evidence to support that topical application of GSPE represents a feasible and productive approach to support dermal wound healing."

•Improving bone strength - Including grape seed extract in your diet with calcium has a "beneficial effect on bone formation and bone strength for the treatment of bone debility caused by a low level of calcium," according to research published in the Journal of Musculoskeletal & Neuronal Interactions.

•Preventing skin cancer - Grape seeds contain proanthocyanidins which can prevent the development of cancer.

A study, published in the journal Molecular Nutrition & Food Research, found that grape seeds have properties that can reduce the severity of skin cancer. The researchers concluded that grape seed extracts "could be useful in the attenuation of the adverse UV-induced health effects in human skin."

•Cardiovascular benefits - The antioxidants in grape seed extract can potentially protect the blood vessels from becoming damaged, which may prevent high blood pressure.

According to one study, published in the journal Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, "grape seed proanthocyanidin extract (GSPE) provides superior antioxidant efficacy as compared to Vitamins C, E and β-carotene."

•Reducing edema (swelling) - Taking grape seed extract can help reduce the swelling that occurs after an injury or surgery.

A double-blind, placebo-controlled study found that breast cancer patients who took 600 mg of grape seed extract every day for 6 months had less edema compared to those on placebo.

•Preventing cognitive decline - Grape seed extract is very high in proanthocyanidins (oligomers of monomeric polyphenols) which may prevent cognitive decline.

One study identified "a critical role for grape seed proanthocyanidin extract (GSPE) as a neuroprotectant in the hippocampus and in preventing cognitive loss with aging."

8 Amazing Benefits of Grapes

Source:http://www.nigeriatoday.ng/2016/06/8-amazing-benefits-of-grapes-5-refreshing-recipes/

(Nigeria Today)

A healthy and well-balanced diet is key to living life to the fullest. Amidst our busy lives; however, none of us really take the time to think about what we use to fuel our bodies. Are we eating the right kinds of food to get us through the day? Are we filling ourselves with the proper nutrients? For the majority of us, we probably aren’t. Fortunately, we can solve this problem one baby step at a time, starting with a step as simple as eating a few grapes a day.

Grapes, you ask? Is that it?

Well, no, it will not solve all of your diet problem. However, striving towards a healthy lifestyle begins with healthy eating. It is not so commonly known that in terms of nutritional value, grapes are some of the most delicious, nutritious, and versatile fruits you can come across.

For those who have not already been enlightened with the extensive health benefits of grapes, here are a few reasons you may want to throw a few in your shopping basket during your next grocery shop.

1.) Aids the treatment of acne

An antioxidant derived from grapes known as resveratrol can prevent the growth of acne-causing bacteria. According to experts, the antioxidant in grapes, combined with prescribed treatments for acne such as benzyl peroxide, can provide effective treatment against acne.

2.) Promotes a healthy digestive system

The abundant presence of fiber and nutrients in grapes allow them to promote a healthy digestive system, assisting in the prevention of constipation and indigestion. A healthy intake of fiber promotes healthy bowel movement. For those lacking in daily fiber intake, grapes are a delicious and low GI way to fill those fiber needs.

3.) Grape seed extract

Grape seed extract (an industrial derivative of grape seeds) is abundant in therapeutic properties, such as the treatment of high cholesterol and the prevention of cancer. The inclusion of grape seed extract, as well as calcium, can improve bone strength and assist in the treatment of bone weakness from low calcium levels.

4.) Assists with management of asthma

A healthy and nutrient-filled diet has been proven to assist with the management of asthma. Studies show that children with a high consumption of fruits (such as grapes) are less likely to have asthma-like symptoms. A component in grape seed extract contains anti-inflammatory properties. Additionally, studies have also shown that grape seed extract improves lung function and increases lung capacity.

5.) Assists with management of diabetes

An extract derived from the skin of grapes (grape skin extract) can be developed and used to aid the management of diabetes. Studies also show that the low GI nature of grapes and grape products can provide health benefits for individuals suffering type-2 diabetes. Due to their high nutritional content and low calorie count, professionals recommend red and black grapes for diabetics.

6.) Lowers the risk of heart disease

Studies suggest that the consumption of grapes or other polyphenols (abundant micronutrients) is associated with a lower risk of heart disease. Grapes contain an extensive variety of polyphenol compounds (such as resveratrol). Daily intake of these nutrients assists with cardiovascular health.

7.) Cancer prevention and longevity

Grapes contain powerful natural chemicals which provide a variety of everyday health benefits, and are even known to assist in the slowing or prevention of cancer. According to studies, these chemicals have the potential to stop the spread of cancer cells. It is also believed that several grape phytonutrients play a role in an individual’s longevity.

8.) Helps protect eyesight

Not only do grapes aid in the prevention of cancer and treatment of diabetes, they are also beneficial for healthy eyesight. Research suggests that regular grape consumption protects retinal structure and function, as well as preventing retinal deterioration.

The Benefits of Grape Seed Extract

Source:http://www.huffingtonpost.com/livestrongcom/the-benefits-of-grape-see_b_646688.html

By Shelley Moore (LIVESTRONG.COM)

Grape seeds contain potent antioxidants, which are substances that neutralize and eliminate harmful free radicals. Some research, primarily with animals, indicates that standardized grape seed extracts may be useful for treating health problems related to free radical damage, according to the the University of Maryland Medical Center (UMMC). The UMMC advises using herbal therapy under the supervision of a health care provider qualified in botanical medicine.

Antioxidants

Vitamin E is an important antioxidant in grape seed, but even more powerful are the flavonoids called oligomeric proanthocyanidin complexes, or OPCs, according to the UMMC. Antioxidants destroy free radicals, which are waste products that develop from the conversion of food to energy and also occur in response to environmental toxins. Free radicals damage cells and genetic material and may contribute to aging and disease, including heart disease and cancer.

Blood Vessel Benefits

Evidence indicates a substantial health benefit for patients with chronic venous insufficiency who take grape seed extract, according to the University of Michigan Health System (UMHS). This disorder causes blood to pool in leg veins, leading to leg swelling and fatigue, as well as pain that worsens when walking. Grape seed extract also may be beneficial for treating varicose veins and capillary fragility, although research is not as consistent, notes the UMHS.

Additionally, the antioxidants in grape seed have a protective effect on blood vessels, which can help prevent high blood pressure. Animal research indicates that grape seed extract lowers blood pressure, according to the UMMC, but research on humans is lacking.

Anti-Cancer Effects

Grape seed antioxidants also may decrease the risk of developing cancer. Additionally, laboratory studies show that grape seed extract prevents the growth of various types of cancer in test tubes, according to the UMMC, including breast, colon, stomach, prostate and lung cancer. Grape seed extract also may protect the liver from cell damage caused by chemotherapy.

Side Effects

Grape seed extract is generally not associated with side effects, according to the UMHS, and excess is removed through urine. The most likely side effects include headache, dizziness, nausea and a dry, itchy scalp, according to the National Center for Complementary and Alternative Medicine. Grape seed extract may have blood-thinning properties, which could increase the risk of bleeding if taken with blood thinning medications.

Usage

Grape seed is available as liquid extract and dried extract in capsules and tablets. The UMMC recommends buying extracts standardized to at least 40 percent proanthocyanidins or at least 95 percent OPCs. To protect against free radical damage, take 25 to 150mg one to three times daily, and for chronic venous insufficiency, take 150 to 300mg once per day. The UMMC advises that children as well as pregnant or breastfeeding women should not take grape seed supplements.

Grapeseed extract shows promise in prevention of cancer

Source:http://www.techtimes.com/articles/139405/20160309/grapeseed-oil-may-reduce-heart-disease-diabetes-risks.htm

By Patrick B. Massey (MD, PH.D.)

Albert Einstein once said "Look deep into nature, and then you will understand everything better."

In regards to the prevention and treatment of cancer, we are discovering that the foods we eat may have significant impact. A case in point is grapeseed extract.

Over the past 10 years, a number of medical studies have demonstrated that grapeseed extract, at least in animal models, can have significant impact on a number of different cancers. Although there are no compelling human clinical studies, grapeseed extract in the animal models of cancer are quite positive.

Grapeseed extract, as the name implies, comes from grapeseed. This particular product is very rich in a number of vitamins, as well as other biologically active compounds such as flavonoids, procyanidins and resveratrol.

Although most of the research into grapeseed extract has been done in animal models, grapeseed extract seems to have a positive effect throughout the entire body.

For example, in animals it has been shown to increase bone density. There is some data indicating that it also is effective at preventing tooth decay and reducing blood pressure. It does exhibit some antibacterial and antiviral activity in a test tube.

Most importantly, grapeseed extract seems to retard cancer cell growth both in the test tube and in animal models. A number of studies over the years have demonstrated that it inhibits the growth of cancer cell lines of lung, breast, prostate and colon cancers.

Some of the most interesting anticancer research has explored the aromatase-inhibiting activity of grapeseed extract and its effect on breast cancer cell growth. One older study published in 2006 demonstrated that grapeseed extract has significant aromatase-inhibiting activity and suppresses the growth of breast cancer cells in the mouse model for breast cancer.

Aromatase is an enzyme that, basically, converts testosterone into estrogen. Many types of breast cancer are stimulated by estrogen and have a very active aromatase enzyme system.

In traditional medicine some chemotherapy agents inhibit the activity of the aromatase enzyme and through that inhibition slow or prevent the growth of estrogen-sensitive breast cancer cells.

This 2006 study, published in Cancer Research, demonstrated that grapeseed extract has significant aromatase-inhibiting activity and greatly reduced the growth of breast cancer cells in mice that are genetically designed to develop breast cancer.

Since this study was published, dozens of other studies have demonstrated that many plants inhibit aromatase activity and may be beneficial for the prevention and treatment of a number of different cancers including breast cancer, colon cancer and prostate cancer.

Even though grapeseed extract may inhibit the growth of breast cancer cells, I do not endorse it as sole treatment for breast cancer.

In addition, there is always concern as to how grapeseed extract affects medications, even though the current data indicates that it is quite safe. A medical physician, board-certified in integrative medicine would be able to provide the best recommendations for the use of grapeseed extract during chemotherapy.

Grape Polyphenols Help Offset Negative Effects of High-fat Diet- Study

Source:http://www.healthnewsline.net/grape-polyphenols-help-offset-negative-effects-high-fat-diet-study/2535311/

By Neelam (Heakth News Line)

Here’s good news for people who love to eat high-fat diet but often avoid it due to fear of health hazards associated with the fatty foods. Now, scientists have found a solution in the form of a natural compound that would allow you to eat what you love without worrying about the saturated fat in these foods.

A recent study has found that grape polyphenols can nullify the adverse negative effects of high fat diet.

Loaded with unique and diverse composition of nutrients and antioxidants called polyphenols, grapes are already known for their health-promoting benefits. Now, the novel research has revealed this little juicy fruit has the potential to negate the negative effects of high fat diet.

In two laboratory studies conducted at the University of North Carolina Greensboro, grapes polyphenols found to be effective in helping counter some of the adverse health consequences of consuming a saturated fat-rich diet.

In the first experiment, the research team discovered that for participants who consumed a high butter-fat diet (33 percent of energy from fat) plus 3 percent whole grapes for 11 weeks the percentage of overall body fat was lowered and subcutaneous fat deposits were reduced.

These reductions led to positive changes in intestinal microbes and health. For instance, it increased the number of some beneficial bacteria, decreased the number of less desirable bacterial strains as well as increased microbial diversity which is good for gut, and enhanced gut barrier function.

In the second experiment, the investigators asked participants to eat even higher fat diet (44 percent of energy from fat) loaded with multiple types of saturated fat, including lard, beef tallow, shortening, and butter for 16 weeks. For the study, the team tried to examine the impact of the high fat diet combined with extracts of either the polyphenol fraction of grapes or the non-polyphenol portion of grapes, as well as the high fat diet enriched with 5 percent whole grapes.

They found that the intake of high-fat diet enriched with grape polyphenols helped reduce the percentage of body fat, subcutaneous and visceral fat depots, and improved glucose tolerance and enhanced intestinal barrier function.

On the other hand, high fat diet plus the 5 percent whole grapes did not appear to improve the metabolic profile in this second study, it did improve the intestinal health though, by increasing microbial diversity and minimizing the number of harmful bacteria in the intestinal tract.

“These two studies suggest that grapes and grape polyphenols may help offset a number of the adverse effects of consuming a high fat diet and trigger improvements in intestinal or systemic health,” said lead investigator Michael McIntosh. “This is an exciting area of health that merits further study.”

Findings from the study were published recently in the Journal of Nutritional Biochemistry.

The Next Amazing Health Food: The Seeds Of Wine Grapes

Source:http://modernfarmer.com/2015/11/wine-grape-nutritional-benefits/

By Dan Nosowitz

There are plenty of studies looking into the mystical healing properties of wine (and plenty of anecdotal studies we could give you about the deliciousness and fun-to-drinkedness of wine). But a new crop of research, including a one published in AgResearch Magazine, focus not on the fermented juice but on the seeds.

Wine grapes, unlike table grapes, almost all have seeds in them; if you’re going to be mashing them for juice, the seeds are going to be discarded anyway, so there’s not much point in selectively breeding the seeds out of them. Those seeds actually have a few benefits; they can be pressed to make grapeseed oil, or they can be fed to livestock as a cheap source of pretty decent fats and proteins. But they aren’t really consumed by humans that much. But maybe they should be!

Wallace Yokoyama, a chemist for the USDA’s Agricultural Research Service, has, among other projects, been working on the possible nutritional and health benefits of grape seeds for a few years now. Yokoyama has been feeding food to rats that’s “spiked,” according to the release, with flour made from pulverized grape seeds. The flours were provided by WholeVine Products, a Sonoma, California, company that sells oils, cookies, and flours made from both the seeds and the skins of Sonoma grapes.

A previous study found that chardonnay seeds—not the seeds of red wine grapes as you might expect—have the highest levels of flavinoids and anti-inflammatory compounds of the varieties tested. That previous study found that chardonnay seed flour, even stripped of its oils, is able to lower the levels of LDL (the bad kind of cholesterol) in the lab animals. The team’s new research focuses on the makeup of the rats’ gut bacteria and how that’s affected by the chemicals in the grape seed flour. They’ve found, according to Yokoyama, “a dramatic decrease in the numbers of gut bacteria,” which the team links to decreases in obesity, diabetes, and cholesterol.

Who knows? Someday soon you may be finding grape seed flour cookies on store shelves near you.

Grape extract kills cancer cells

Source:http://news.bbc.co.uk/2/hi/health/7803619.stm

(BBC News)

An extract from grape seeds can destroy cancer cells, US research suggests.

In lab experiments, scientists found that the extract stimulated leukaemia cells to commit suicide.

Within 24 hours, 76% of leukaemia cells exposed to the extract were killed off, while healthy cells were unharmed, Clinical Cancer Research reports.

The study raises the possibility of new cancer treatments, but scientists said it was too early to recommend that people eat grapes to ward off cancer.

Grape seeds contain a number of antioxidants, including resveratrol, which is known to have anti-cancer properties, as well as positive effect on the heart.

Previous research has shown grapeseed extract has an effect on skin, breast, bowel, lung, stomach and prostate cancer cells in the laboratory.

It can also reduce the size of breast tumours in rats and skin tumours in mice.

However, the University of Kentucky study is the first to test its impact on a blood cancer.

Lead researcher Professor Xianglin Shi said: "These results could have implications for the incorporation of agents such as grapeseed extract into prevention or treatment of haematological (blood) malignancies and possibly other cancers.

"What everyone seeks is an agent that has an effect on cancer cells but leaves normal cells alone, and this shows that grapeseed extract fits into this category."

The researchers exposed leukaemia cells to grape extract in a range of different doses.

Apoptosis

One of the higher doses produced a marked effect, causing large numbers of the cells to commit suicide in a process known as apoptosis.

This is a natural method of getting rid of damaged and potentially dangerous cells.

When the mechanism behind apoptosis breaks down, cancerous cells can survive and multiply.

The researchers found grapeseed extract activates a protein called JNK which helps to regulate apoptosis.

When they exposed the leukaemia cells to an agent that inhibits JNK, the grapeseed extract effect was cancelled out.

Silencing the gene that makes JNK also blocked the extract's ability to kill cancer cells.

Kat Arney, Cancer Research UK's senior cancer information officer, warned against jumping to firm conclusions.

She said: "This is yet another story highlighting the potential cancer-fighting properties of naturally-occurring chemicals.

"Although interesting, it's still a long way from being a treatment that we can give to patients."

Reaping the benefits of grapeseed oil

Source:http://www.business-standard.com/article/beyond-business/reaping-the-benefits-of-grapeseed-oil-116032500772_1.html

By Avantika Bhuyan

A new study suggests that it may be healthier than olive oil

The one question that has baffled and needled fitness enthusiasts for eternity is: which oil is the best for you? Our kitchen shelves have seen oils come and go -the oil regime shifting from years of greasy vanaspati to the era of clear vegetable oils and finally settling on to the rule of the olive oil. However, if a new study is to be believed, there is an oil that is healthier than olive oil, and that's grapeseed. Imbued with linoleic acid, the lipids found in grapeseed oil lower the risk of diabetes and heart disease. These lipids are, however, missing in olive oil, suggests the study conducted by researchers at the Ohio State University, which was published online in the journal Molecular Nutrition & Food Research.

According to a media statement by the Ohio State University, researchers found that men and women with higher linoleic acid levels tended to have less heart-threatening fat nestled between their vital organs, more lean body mass and less inflammation. Moreover, higher linoleic acid levels meant lower likelihood of insulin resistance, a precursor to diabetes. "This finding could have obvious implications in preventing heart disease and diabetes, but also could be important for older adults because higher lean body mass can contribute to a longer life with more independence," stated Martha Belury, professor of human nutrition, who led the research.

Grapeseed is not the only source of linoleic acid - safflower, sunflower and soybean oils contain it too - but it remains the best, with linoleic acid constituting 80 per cent of its fatty acids. "It has some very powerful antioxidants too, helps fight ageing and diseases, is great for the skin," says Ishi Khosla, clinical nutritionist and founder, weightmonitor.com. "And, most important, it is universally suited to all body and health types."

It also bears good news for all those who love to whip up an Indian feast and were earlier unable to do so with olive oil. "It has a very high smoking point, unlike olive oil. While the latter doesn't allow for deep frying or for cooking Indian subzis, but with grapeseed you can do all that," says Shikha Sharma, wellness expert and founder of Nutri-Health.

The fact that it is so light and odourless has made it quite a favourite with chefs, particularly those who specialise in Mediterranean fare. Sujan Sarkar, chef de cuisine, Olive Qutub, for instance, makes a mimosa dressing with grapeseed oil and orange for salads. Vikram Khatri, executive chef, Guppy by ai, too uses it to make dressings and for sauteeing. "It gives a clean, light-bodied feel with no aftertaste," says Khatri, who suggests storing the oil in the refrigerator after opening. "It's not just a great source of linoleic, but also of Vitamin D and Omega 6."

However, experts caution not to dismiss olive oil altogether. "While grapeseed oil is polyunsaturated, olive oil has monounsaturated fatty acid and Omega 3, which is great for the nervous system," says Sharma. There is no reason why grapeseed and olive oils can't coexist. "Ideally, one should have a mix of different oils in the diet," she says.

The one factor that is hindering grapeseed oil's progress from the shop shelf to the kitchen is its cost. On a popular grocery shopping website, while a 100 ml bottle of olive oil costs Rs 110, a similar quantity of grapeseed oil is priced at Rs 200. "It is too expensive as of now to be used as a mass cooking medium," says Khosla.

Move over olive oil, grapeseed oil can be your heart's favourite health buddy

Source:http://indiatoday.intoday.in/story/move-over-olive-oil-grapeseed-oil-can-be-your-hearts-favourite-health-buddy/1/613723.html

(IndiaToday.in)

Grapeseed oil is an excellent source of linoleic acid, which constitutes about 80 percent of fatty acids that the body needs.

A diet rich in a fatty acids which is vital for nutrition and is found in grapeseed and other oils (but not in olive oil) may decrease the risk of heart disease and diabetes, according to a new study.

The results showed that men and women with higher linoleic acid levels--which contains omega-6 fatty acid--are less prone to heart disease and inflammation and also possess more lean body mass. Higher linoleic acid levels also means lower likelihood of insulin resistance, which is a precursor to diabetes.

"This finding could have obvious implications in preventing heart disease and diabetes, but also could be important for older adults because higher lean body mass can contribute to a longer life with more independence," said Martha Belury, professor at Ohio State University.

Grapeseed oil for now remains an excellent source of linoleic acid, which constitutes about 80 percent of its fatty acids. Corn oil also remains a decent source, the researchers noted. However, the general consumption of linoleic acid is declining because of genetic modification of plants for food manufacturers seeking oils higher in oleic acid. The industry's push against trans fats can be one possible reason.

"Vegetable oils have changed. They're no longer high in linoleic acid," Belury pointed out. When linoleic acid gets solid (hydrogenated) for processed foods, it is more likely to convert to trans fat than its oleic cousin.

So oils, notably safflower, sunflower and soybean, now routinely contain less linoleic acid--it often makes up less than 20 percent of the fatty acids in commonly purchased oils, based on food labels and confirmed by testing in her lab, Belury explained.

The study, published in the journal Molecular Nutrition & Food Research, is the first to examine linoleic acid alongside body composition and other health markers in people who hadn't been given supplements or prescriptive diets, the researchers noted.

Compound in grape seed extract 'kills prostate cancer cells'

Source:http://www.medicalnewstoday.com/articles/269775.php

By Honor Whiteman

New research suggests that a component found in grape seed extract is effective in killing prostate cancer cells. This is according to a study published in the journal Nutrition and Cancer.

Investigators from the University of Colorado Cancer Center have analyzed the potential of grape seed extract (GSE) for its anti-cancer properties over the last 10 years.

But although previous research from the team has demonstrated its effectiveness against cancer cells and how it works, it was unknown as to which element of GSE produces these effects.

"This naturally occurring compound, GSE, is a complex mixture of polyphenols and, so far, it has been unclear about the biologically active constituents of GSE against cancer cells," says Alpna Tyagi, of the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences. Grape seeds Researchers have pinpointed a compound in grape seed extract called B2G2, which they discovered can successfully induce human prostate cancer cell death.

In the new study, however, the researchers discovered that a component of GSE called B2G2 is the most active against cancer cells.

But they say that isolating the compound from GSE is very costly and takes a long time, which halted any further experiments using this process.

Therefore, they decided to synthesize the B2G2 compound from GSE instead. The study details how the researchers were able to synthesize gram-quantity of the compound much faster than if they were to purify it from GSE, and this method was much more cost-effective.

"We've shown similar anti-cancer activity in the past with grape seed extract, but now we know B2G2 is its most biologically active ingredient, which can be synthesized in quantities that will allow us to study the detailed death mechanism in cancer cells," says Tyagi. B2G2 successfully triggered cancer cell death

As part of the study, the research team tested the synthesized B2G2 compound on human prostate cancer cells.

The compound was found to induce cancer cell death, known as apoptosis, but left healthy cells unharmed.

The investigators say that their findings mean they are a step closer to understanding the possible effects and mechanisms of active components in GSEs that are effective against cancer cells.

Tyagi adds:

"Isolating and synthesizing B2G2 is an important step because now we have the ability to conduct more experiments with the pure compound.

Ongoing work in the lab further increases our understanding of B2G2′s mechanism of action that will help for the preclinical and clinical studies in the future."

Other research has also reported positive effects of grape compounds against cancer.

Earlier this year, Medical News today reported on a study suggesting that resveratrol - a compound found in grape skin and red wine - may help treat several cancers, while another study suggested that grape seed extract is effective in the treatment of colorectal cancer.

Grapeseed extract shows promise in prevention of cancer

Source:http://www.dailyherald.com/article/20151115/entlife/151119636/