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Grape Fruits

Dietary supplement is a product that contains vitamins, minerals, herbs or other botanicals, amino acids, enzymes, and/or other ingredients intended to supplement the diet. The U.S. Food and Drug Administration has special labeling requirements for dietary supplements and treats them as foods, not drugs.

Manufacturers and distributors of dietary supplements and dietary ingredients are prohibited from marketing products that are adulterated or misbranded. That means that these firms are responsible for evaluating the safety and labeling of their products before marketing to ensure that they meet all the requirements of DSHEA and FDA regulations.

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Immune System Supplements Astragalus root is used to support and enhance the immune system. Astragalus has also been used for heart disease. Herbal Alternative Health

Grape Seed

The medicinal herb Grape Seed Extract as an alternative herbal remedy - The grape seeds used to produce this extract are generally obtained from wine manufacturers.

What Grape seed extract Is Used For

Grape seed extract is used as an herbal remedy for conditions related to the heart and blood vessels, such as atherosclerosis (hardening of the arteries), high blood pressure, high cholesterol, and poor circulation.
Other reasons for the use of grape seed extract include complications related to diabetes, such as nerve and eye damage; vision problems, such as macular degeneration (which can cause blindness); and swelling after an injury or surgery.
Grape seed extract is also used for cancer prevention and wound healing.

How Grape seed extract Is Used

Grape seed extract is prepared from the seed of grapes. It is available in capsule and tablet forms.

What the Science Says about Grape seed extract

Laboratory studies have shown that grape seed contains antioxidants-substances that prevent cell damage caused by free radicals, which are highly reactive molecules that can damage cell function. However, it is still unclear how grape seed might affect human health.
Grape seed extracts have shown some beneficial antioxidant effects in preliminary clinical trials. However, few trials have looked at specific diseases or conditions, and little scientific evidence is available.
A study funded by the National Cancer Institute (NCI) found that grape seed extract did not reduce the hardening of breast tissue that can occur after radiation therapy for breast cancer.
NCI is also funding studies evaluating whether grape seed extract is effective in preventing breast and prostate cancers.
NCCAM is studying whether the action of grape seed extract and its components may benefit the heart or have protective effects in the brain.

Side Effects and Cautions of Grape seed extract

Grape seed extract is generally well tolerated when taken by mouth. It has been used safely for up to 8 weeks in clinical trials.
Side effects that have been reported most often include headache; a dry, itchy scalp; dizziness; and nausea.
The interactions between grape seed extract and medicines or other supplements have not been carefully studied.
Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

News About Grape Seed

Grape seeds extract can destroy cancer cells in just one day

Source:http://www.express.co.uk/news/uk/77942/Grape-seeds-extract-can-destroy-cancer-cells-in-just-one-day

By Jo Willey (Health Correspondent)

A SUPPLEMENT made from grape seeds can destroy three-quarters of leukaemia cancer cells within just 24 hours, scientists have found.

The remarkable discovery is being hailed by experts after researchers claimed the finding could pave the way to promising new treatments for the disease, which affects thousands of people in the UK every year.

Laboratory experiments on a commercially-available grape seed extract forced cancer cells to “commit suicide”.

Within 24 hours, 76 per cent of leukaemia cells exposed to the extract died through a process of natural self-destruction called apoptosis, leaving healthy cells unharmed.

Grape seeds contain a number of antioxidant plant chemicals, including resveratrol, the “wonder ingredient” in red wine, which is known to have anti-cancer properties.

Previous research has shown that grapeseed extract has an effect on skin, breast, bowel, lung, stomach and prostate cancer cells in the laboratory.

It can also reduce the size of breast tumours in rats and skin tumours in mice, but it has never before been tested on blood cancer.

Earlier this year scientists claimed that resveratrol – found in the skin of red grapes – is a potent anti-ageing compound. In this latest study, US researchers found that grape seed extract strongly activates a protein called JNK which helps to regulate apoptosis.

When the scientists exposed the leukaemia cells to an agent that inhibits JNK, the grape seed extract effect was cancelled out.

Silencing the gene that makes JNK also blocked the extract’s ability to kill cancer cells.

Professor Xianglin Shi, from the University of Kentucky in Philadelphia, who led the research, said: “These results could have implications for the incorporation of agents such as grape seed extract into prevention or treatment of blood malignancies and possibly other cancers.

“What everyone seeks is an agent that has an effect on cancer cells but leaves normal cells alone, and this shows that grape seed extract fits into this category.”

Prof Shi exposed leukaemia cells to grape extract in a range of different doses.

One of the higher doses produced a marked effect, causing large numbers of the cells to destroy themselves.

Programmed cell suicide is a natural method of getting rid of damaged and potentially dangerous cells. When the mechanism behind apoptosis breaks down, cancerous cells can survive and multiply.

“This is a natural compound that appears to have relatively important properties,” said Prof Shi.

Information on Germinating Grape Seeds

Source:http://healthyeating.sfgate.com/health-benefits-dried-grape-seed-extract-7055.html

(San Francisco Gate)

Germinating grape seeds offers a challenge to any green thumb, thanks to inviable seeds and plenty of opportunity for contamination. Fortunately, careful preparation can increase the germination percentage for a healthy vineyard in the summer. During stratification, temperature and moisture need monitoring to ensure grape seeds are ready for germination and planting in the spring.

Choosing Viable Seeds

You can usually tell a viable seed by the way it looks and feels. Healthy seeds are firm, with a pale white or gray endosperm inside. Any seeds that are squishy when you gently squeeze them between your fingers are not viable. To double-check this, you can drop the seeds in water and discard those that float to the top, as healthy seeds tend to sink.

Preparation

Before stratification, viable seeds need a thorough washing to remove the pulp. Soaking the grape seeds in distilled water for 24 hours before stratification increases the odds of germination. Because the seeds need to remain semi-moist during stratification, you'll need to prepare a proper bed for them, such as an air-tight bag or capsule filled with damp sand or wet paper towels. Damp peat moss is one of the best beds for grape seeds, as it has anti-fungal properties that can reduce the risk of mold that destroys the seeds during stratification. Stratification

Once you prepare the bed, you can tuck the seeds inside it and refrigerate them at 40 degrees Fahrenheit for about three months. You can safely store seeds in the fridge for a year or more, as they will not sprout in these conditions. The smartest time to do this is in December, as March is the time for planting in a greenhouse.

Germination

After removing the seeds from stratification in early spring, you can plant them in small pots, or in larger pots with at least 1 1/2 inches of space between them. A greenhouse is the safest place for them until June, when you can transplant them to their permanent places outside. They need temperatures reaching at least 70 degrees Fahrenheit by day and approximately 60 degrees Fahrenheit at night during this germination period. The time it takes the seeds to germinate varies from approximately two weeks to two months; sometimes receiving 15 hours of sunlight per day encourages them to germinate sooner rather than later. If some seeds don't germinate, you can always pop them back in the fridge for stratification until next season and try again then.

What Are the Health Benefits of Dried Grape Seed Extract?

Source:http://healthyeating.sfgate.com/health-benefits-dried-grape-seed-extract-7055.html

By Tracey Roizman, DC

Grapes and grape plants, including the leaves and sap from the vines, have been used for food and medicinal purposes for over 6,000 years, according to the University of Maryland Medical Center. Grape seeds are high in vitamin E, flavonoid antioxidants, the omega-6 fatty acid called linoleic acid, and certain antioxidants. Dried grape seed extract provides a number of potential health benefits. Swelling and Inflammation

Grape seed extract reduces swelling and can help decrease edema -- surgery or injury-induced swelling -- that occurs following breast cancer surgery in some women, according to the University of Maryland Medical center. Doses of 600 milligrams per day have been used for six months after surgery and resulted in less pain and swelling. Blood Pressure

Lower blood pressure is one of the potential benefits of supplementing with grape seed extract, according to the University of California Davis School of Medicine. Typical dosages of 150 to 300 milligrams per day have been used to treat high blood pressure and other medical conditions, notes New York University's Langone Medical Center. A study published in the December 2009 issue of the journal "Metabolism" reported blood pressure-lowering benefits of both 150 milligrams and 300 milligrams per day for four weeks.

Blood Sugar

A study published in the July 2012 issue of the journal "Pharmacognosy Magazine" found that grape seed extract reduced blood sugar levels after high-carbohydrate meals. In the study of healthy volunteers, 100 milligrams of grape seed extract taken together with a high-carbohydrate meal resulted in 52 percent lower spikes in blood sugar 30 minutes after the meal than a high-carbohydrate control meal that did not include grape seed extract. Doses of 300 milligrams of grape seed extract resulted in 72 percent lower rises in blood sugar than the control meal 30 minutes after the meal.

Dental Health

Grape seed extract helped prevent cavity formation and promoted remineralization of teeth in a laboratory study published in the July 2012 issue of the "Journal of Contemporary Dental Practice." Researchers induced artificial cavities in human teeth and concluded that grape seed extract may prove to be a useful natural means for preventing tooth decay. Further studies are needed to determine whether these benefits occur outside of the laboratory setting.

Asthma and Allergies

Anti-inflammatory benefits of grape seed extract might make it a useful supplement for managing asthma, according to Wishard Health. Grape seed extract inhibits histamine production, which reduces the symptoms of nasal allergies and also helps relax the muscles that line airways. A laboratory animal study that appeared in the July 2012 issue of the "Journal of Clinical Immunology" found that eight weeks of grape seed extract supplementation significantly reduced airway constriction, decreased inflammatory cells and reduced inflammation in the lungs. Grape seed extract also reduced scarring in the lungs. Further studies are needed to determine whether these benefits extend to humans.

Is Grape Seed Extract Good for the Eyes?

Source:http://healthyeating.sfgate.com/grape-seed-extract-good-eyes-7456.html

By Tracey Roizman, DC

Grapes have been an integral part of human culture and cuisine for thousands of years. They provide a highly nutritious food source and have been used, along with the leaves, in various folk remedies for conditions ranging from sore throat to cancer, according to the University of Maryland Medical Center. Grape seeds, chock full of powerful antioxidants, have caught the interest of scientists and the health-conscious public and may offer benefits for a variety of health conditions, including some related to visual health.

Night Vision

Night vision may improve with grape seed extract supplementation, the University of Maryland Medical Center reports. A study published in the April 2012 issue "Current Eye Research" found that antioxidants in grape seeds protect cells in the retina, which are responsible for your ability to distinguish colors and to see in low-light conditions. In the tissue culture study, grape seed extract quenched free radicals, reversed oxidative damage and protected retinal cells from stress-induced early demise.

Macular Degeneration

Oligomeric proanthocyanins in grape seed extract may help prevent or slow the development of macular degeneration, a condition involving loss of the central field of vision, according to medicinal chemistry lecture notes from the University of Washington. Dr. Theresa Graedon, co-author of "The People's Pharmacy Guide to Home and Herbal Remedies," recommends grape seed extract for slowing macular degeneration as well as reducing visual stress caused by computer screens. Doses of 50 to 100 mg per day are common for general health and wellness. Therapeutic doses for particular conditions may go as high as 300 mg per day.

Cataract Prevention

Cataracts might be preventable, in part, by grape seed extract use, according to a tissue culture study published in the January 2011 "Molecular Vision." In the study, grape seed extract reduced oxidative damage to human lens cells exposed to hydrogen peroxide. Researchers concluded that grape seed extract may be useful for preventing or reversing oxidative damage that can lead to cataract formation. A laboratory animal study published in the June 2006 issue of "Journal of Cataract and Refractive Surgery" found that doses of 100 mg per kilogram body weight of grape seed proanthocyanidins effectively prevented cataract formation. Further clinical trials are needed to confirm these preliminary results.

Considerations

Safety of grape seed extract was addressed in a laboratory animal study published in the March 2001 "Research Communications in Molecular Pathology and Pharmacology." Short-term testing showed that grape seed extract was safe when given in single doses as high as 5,000 mg per kilogram body weight. Long-term tests showed that grape seed extract produced no toxic effects to the brain, heart, intestine, kidney, liver, lung or spleen at doses of 100 mg per kilogram body weight for 12 months.

Can You Drink Grape Seed Oil?

Source:http://healthyeating.sfgate.com/can-drink-grape-seed-oil-11312.html

By William McCoy

If you typically use oils such as vegetable oil and olive oil for your cooking, it's time to consider adding a different type with a slightly tastier name. The use of grape seed oil, which is made from the seeds of red grapes, can benefit your health in a number of ways. Even if you're anxious to get the benefits of this oil, you don't have to go to the length of drinking it. Don't Try Drinking It

Grape seed oil is a healthy type of oil to include in your diet. It has a multitude of uses in the kitchen and can easily replace other oils with which you might typically cook. Although no health organizations caution against drinking grape seed oil, you can consume the oil in better ways. Despite its name, this type of oil doesn't have a taste reminiscent of grapes, and its thick, oily texture isn't enjoyable to swallow.

Keep Your Oil Intake Low

Part of the reason you shouldn't try to drink grape seed oil is because, taste and texture aside, you don't need to consume a significant amount of this oil. Provided you get at least 30 minutes of physical activity, ChooseMyPlate.gov cautions against consuming oil in excess of 7 teaspoons per day. Women between 19 and 30 years of age should consume up to 6 teaspoons of oil daily and 5 teaspoons after the age of 30. For men, an intake of 7 teaspoons per day is appropriate between the ages of 19 and 30. After 30, men should limit their oil intake to 6 teaspoons.

Uses for Grape Seed Oil

You don't have to resort to drinking grape seed oil because you can include it in your diet in several easier-to-stomach ways. This type of oil is ideal to use for frying because it has virtually no taste that could otherwise affect your food. It also won't smoke even at high temperatures. Grape seed oil can work in your deep fryer or frying pan. It can also serve as an ingredient in homemade salad dressings.

A Healthy Source of Vitamin E

Grape seed oil is notable for its high concentration of vitamin E. One tablespoon of the oil has 3.9 milligrams of this vitamin. The same amount of corn, peanut or olive oil has just 2.1 milligrams of vitamin E. Your recommended dietary allowance of vitamin E is 15 milligrams per day. In your body, vitamin E serves as an antioxidant, improves your immune system and contributes to cell function.

Grape Seed Oil Health Benefits

Source:http://www.thehealthsite.com/news/can-grape-seeds-cure-prostate-cancer/

(Editorial Team, The Health Site)

A component in grape seed extract has been shown to kill cancerous prostate cells, while leaving healthy cells unharmed, Indian-origin scientists have found. A new study describes the laboratory synthesis of the most active component of grape seed extract, B2G2, and shows this synthesised compound induces the cell death known as apoptosis in prostate cancer cells while leaving healthy cells unharmed.

‘We’ve shown similar anti-cancer activity in the past with grape seed extract (GSE), but now we know B2G2 is its most biologically active ingredient which can be synthesised in quantities that will allow us to study the detailed death mechanism in cancer cells,’ said Alpna Tyagi, of the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences. The group has spent more than a decade demonstrating the anti-cancer activity of GSE in controlled, laboratory conditions.

For example, previous studies have shown the GSE effectiveness against cancer cells and have also shown its mechanism of action. ‘But until recently, we didn’t know which constituent of GSE created this effect. This naturally occurring compound, GSE, is a complex mixture of polyphenols and also so far it has been unclear about the biologically active constituents of GSE against cancer cells,’ said Tyagi, who works in the lab of CU Cancer Center investigator, Chapla Agarwal.

Eventually the group pinpointed B2G2 as the most active compound, but, ‘it’s expensive and it takes a long time to isolate B2G2 from grape seed extract,’ Tyagi said. So instead of purifying B2G2 from GSE, the group decided to synthesise it in the lab. The study reported the success of this effort, including the ability to synthesise gram-quantity of B2G2 reasonably quickly and inexpensively.

The group showed anti-cancer activity of synthesised B2G2 similar in mechanism and degree to overall GSE effectiveness. ‘Our goal all along has been a clinical trial of the biologically active compounds from GSE against human cancer. But it’s difficult to earn FDA approval for a trial in which we don’t know the mechanisms and possible effects of all active components.

‘Therefore, isolating and synthesising B2G2 is an important step because now we have the ability to conduct more experiments with the pure compound. Ongoing work in the lab further increases our understanding of B2G2′s mechanism of action that will help for the preclinical and clinical studies in the future,’ said Tyagi.

The study was published in the journal Nutrition and Cancer.

What is cancer?

Cancer is a group of over one hundred diseases characterised by abnormal, uncontrolled cell growth. Ina healthy body cells grow, die and are replaced in a very controlled way. Damage or change in the genetic material of cells by environmental or internal factors result in cells that don’t die and continue to multiply until a massive cancer or a tumour develops. Most cancer related deaths are due to metastasis, malignant cells that penetrate into the circulatory system and establish colonies in other parts of the body.

Grape Seed Oil Health Benefits

Source:http://healthyeating.sfgate.com/grape-seed-oil-health-benefits-6827.html

By Joanne Marie

Grapes have been recognized for their food and medicinal value for thousands of years; philosophers wrote of the healing powers of grapes in the time of ancient Greece. Today, modern science recognizes that the oily extract of grape seeds is a source of antioxidants and other biologically active compounds that may help keep you healthy and disease-free.

Antioxidant Benefits

Grape seeds are separated from grapes when they are pressed to make wine. Grinding the seeds releases an oil that contains a number of fatty compounds, some proteins, vitamin E and plant compounds called flavonoids. One class of flavonoids, oligomeric proanthocyanidins, or OPCs, contains especially potent antioxidants that may have significant health benefits. Antioxidants stabilize free radicals, which are unstable chemicals formed in your body as byproducts of digestion or after you are exposed to environmental toxins. Free radicals can speed aging and raise your risk of cancer and other diseases. When stabilized by antioxidants, they become harmless and your body can easily dispose of them.

Cardiovascular Benefits

Many research studies suggest that grape seed oil has cardiovascular benefits. For example, a study published in "Journal of Medicine" found that subjects with high cholesterol who consumed grape seed extract along with chromium for two months had lowered cholesterol levels, compared to groups who consumed a placebo or the extract or chromium alone. In a review of clinical trials published in "Journal of the American Dietetic Association," the authors concluded that compounds in grape seeds can significantly lower blood pressure and reduce heart rates in human subjects. A laboratory study published in "Mutation Research" identified several mechanisms through which OPCs in grape seeds improve heart function, leading the authors to suggest that grape seed oil might be a useful therapeutic tool.

Other Benefits

Memorial Sloan-Kettering Cancer Center reports that compounds in grape seeds may have anti-cancer properties, citing a study in "Cancer Epidemiology, Biomarkers and Prevention" in which many supplements were evaluated for their possible use in preventing cancer. The authors concluded that grape seed extracts may lower the risk of developing certain cancers of the circulatory system. Cancer Center experts also report that grape seed extracts inhibit growth of cultured cancer cells in the laboratory and could increase the anti-cancer effects of some chemotherapy drugs. According to the University of Maryland Medical Center, grape seed oil can also speed recovery from swelling or edema caused by surgery or an injury, and it may improve symptoms of venous insufficiency, a disorder of the veins in your legs.

How To Use It

Grape seed oil is available at some food markets as bottled oil or from health food stores as oil or extract in capsules, tablets or liquid. For maximum health benefit, choose oil or extract standardized for its content of OPCs. Generally considered safe and without significant side effects, grape seed oil or extract might cause mild nausea, stomach upset or diarrhea in some people and might interact with certain medications, including blood-thinners or drugs broken down in your liver. Do not consume grape seed extract if you are pregnant or breast-feeding. Talk to your doctor before consuming the oil or extract to decide what is best for your situation.

The Benefits of Grape Seed Extract

Source:http://www.huffingtonpost.com/livestrongcom/the-benefits-of-grape-see_b_646688.html

By Shelley Moore (LIVESTRONG.COM)

Grape seeds contain potent antioxidants, which are substances that neutralize and eliminate harmful free radicals. Some research, primarily with animals, indicates that standardized grape seed extracts may be useful for treating health problems related to free radical damage, according to the the University of Maryland Medical Center (UMMC). The UMMC advises using herbal therapy under the supervision of a health care provider qualified in botanical medicine.

Antioxidants

Vitamin E is an important antioxidant in grape seed, but even more powerful are the flavonoids called oligomeric proanthocyanidin complexes, or OPCs, according to the UMMC. Antioxidants destroy free radicals, which are waste products that develop from the conversion of food to energy and also occur in response to environmental toxins. Free radicals damage cells and genetic material and may contribute to aging and disease, including heart disease and cancer.

Blood Vessel Benefits

Evidence indicates a substantial health benefit for patients with chronic venous insufficiency who take grape seed extract, according to the University of Michigan Health System (UMHS). This disorder causes blood to pool in leg veins, leading to leg swelling and fatigue, as well as pain that worsens when walking. Grape seed extract also may be beneficial for treating varicose veins and capillary fragility, although research is not as consistent, notes the UMHS.

Additionally, the antioxidants in grape seed have a protective effect on blood vessels, which can help prevent high blood pressure. Animal research indicates that grape seed extract lowers blood pressure, according to the UMMC, but research on humans is lacking.

Anti-Cancer Effects

Grape seed antioxidants also may decrease the risk of developing cancer. Additionally, laboratory studies show that grape seed extract prevents the growth of various types of cancer in test tubes, according to the UMMC, including breast, colon, stomach, prostate and lung cancer. Grape seed extract also may protect the liver from cell damage caused by chemotherapy.

Side Effects

Grape seed extract is generally not associated with side effects, according to the UMHS, and excess is removed through urine. The most likely side effects include headache, dizziness, nausea and a dry, itchy scalp, according to the National Center for Complementary and Alternative Medicine. Grape seed extract may have blood-thinning properties, which could increase the risk of bleeding if taken with blood thinning medications.

Usage

Grape seed is available as liquid extract and dried extract in capsules and tablets. The UMMC recommends buying extracts standardized to at least 40 percent proanthocyanidins or at least 95 percent OPCs. To protect against free radical damage, take 25 to 150mg one to three times daily, and for chronic venous insufficiency, take 150 to 300mg once per day. The UMMC advises that children as well as pregnant or breastfeeding women should not take grape seed supplements.

3 ways grapes can protect your kidneys

Source:http://www.thehealthsite.com/diseases-conditions/ways-grapes-can-protect-your-kidneys-v1215/

By Anuradha Varanasi

Grapes can safeguard your kidney's health and also reverse kidney damage! Here's how...

While the burden of kidney diseases in India can’t be assessed accurately, the approximate prevalence of chronic kidney disease is as high as 800 per million population . The leading cause of kidney diseases among Indians is diabetic nephropathy. However, you can avoid the risk of kidney diseases and safeguard your health by consuming grapes. Various studies have established that grape seeds extract and a component found in grapes called resveratrol are effective in protecting your kidneys, especially for diabetics. You can improve your kidney’s health by adding a glass of grape juice or at least 15 grapes a day to your diet, as per the recommendation of the National Kidney Foundation. Here’s how this fruit is beneficial for your kidneys. Other than this, red grapes can also boost your immunity.

Can reverse kidney damage

A study published in Applied Physiology, Nutrition, and Metabolism found that the compounds found in grape seed and skin can reverse kidney damage caused by a high fat diet . Obese people are more prone to kidney damage as it can lead to depletion of copper from the kidney, among other complications. The study suggests using grape seed and skin extracts as a preventive supplement for patients at a high risk of kidney disease due to obesity. Grapes is a great source of antioxidants, which protects the body against oxidative stress, which is the imbalance between production of free radicals and antioxidant defences.

Prevention of kidney disease

Around 50% of patients suffer from acute renal failure due to inadequate blood supply to the kidneys, or what is known as ischemia. Grapes have anti oxidant and anti-inflammatory mechanisms as the compound resveratol reduces the risk of damage caused by ischemia . Resveratol was found to have a protective effect in rats’ kidneys who were suffering from tissue damage caused by the return of blood supply to the kidneys, after a period of lack of oxygen supply or ischemia. This study was conducted by Italian doctors from the University of Milan in 2013.

Reduction of renal disturbances

Iranian researchers found that 50 mg of grape seeds extracts a day for two weeks may reduce kidney function disturbances following tissue damage caused by ischemia . The study was conducted on 32 rats in 2013 and researchers hope that this finding will be able to reduce the harmful effects of renal disturbances. Here are 5 other foods that can help you recover from kidney disease.

Grape seed, chemo combo could treat bowel cancer

Source:http://www.dailyherald.com/article/20151115/entlife/151119636/

(AAP)

Grape seed can be combined with chemotherapy to improve treatment for bowel cancer, according to Australian scientists.

They say the wine-making by-product reduces intestinal damage caused by chemotherapy and enhances its effect.

It reduces inflammation and tissue damage caused by chemotherapy in the small intestine, says Dr Amy Cheah, lead author of an article about the study published in the journal PLOS ONE.

"Unlike chemotherapy, grape seed appears to selectively act on cancer cells and leave healthy cells almost unaffected," said the University of Adelaide researcher.

Commercially available grape seed extract was used in the study which involved laboratory tests on cell cultures.

Co-author and project leader Professor Gordon Howarth said: "Grape seed is showing great potential as an anti-inflammatory treatment for a range of bowel diseases and now as a possible anti-cancer treatment."

Compound In Grape Seed Extract Causes Prostate Cancer Cell Death

Source:http://www.medicaldaily.com/compound-grape-seed-extract-causes-prostate-cancer-cell-death-264683

By Anthony Rivas

A compound in grape seed extract has been shown in lab tests to kill prostate cancer cells and prevent their growth.

Grape seed extract’s abundance in bioflavonoid compounds known as procyanidins, which are also found in apples and chocolate, has led many to use it as a supplement for its many health benefits. One of the most promising pieces of research into the bioflavonoids is that they were able to kill prostate cancer cells. Until now, however, researchers didn’t know which specific compound was mostly responsible for this process. In a new study, researchers detail how they were able to synthesize the responsible compound, and showed how it killed the cancer cells.

Researchers from the University of Colorado Cancer Center had previously looked into procyanidins’ potential to kill cancer cells. “This naturally occurring compound, grape seed extract, is a complex mixture of polyphenols and, so far, it has been unclear about the biologically active constituents of grape seed extract against cancer cells,” Alpna Tyagi, of the University of Colorado Skaggs School of Pharmacy and Phamaceutical Sciences, said in a press release.

The team of researchers found that the procyanidin B2G2 was the most active compound against prostate cancer cells, however, isolating large enough quantities from the grape seed extract was time consuming and expensive. Isolating larger quantities would have been even more difficult. So instead, they decided that synthesizing the compound would be the best route, and they were right — they were left with a completely pure form of the compound at a fraction of the cost and time. Upon testing the compound on prostate cells, they found that both the isolated compound and the synthesized compound inhibited cell growth and caused cell death, which is known as apoptosis.

“Our goal all along has been a clinical trial of the biologically active compounds from grape seed extract against human cancer,” Tyagi said in the statement. “But it’s difficult to earn FDA approval for a trial in which we don’t know the mechanisms and possible effects of all active components.” By overcoming this challenge, Tyagi’s team has moved that much closer to conducting studies on the compound’s effect on prostate cancer outside of a petri dish.

Aside from prostate cancer, the procyanidins in grape seed extract have also been found to have other health benefits. According to the National Institutes of Health, grape seed extract can alleviate chronic venous insufficiency, allowing blood to flow more freely from the legs to the heart, and it can reduce eye and blood vessel problems associated with diabetes.

Grape Seed Extract Benefits Blood Pressure and Cholesterol

Source:http://universityhealthnews.com/daily/heart-health/grape-seed-extract-benefits-blood-pressure-and-cholesterol/

(UHN Staff)

Grape seed extract contains a high percentage of compounds called oligomeric proanthocyanidins.

Six thousand years ago, the Egyptians recognized the healing power of grapes although they didn’t fully understand why the fruit is so beneficial. Today, we now know how grape seed extract works to naturally lower blood pressure and cholesterol levels. Grape seed extract contains a high percentage of compounds called oligomeric proanthocyanidins (OPCs for short). OPCs from grape seed extract are flavonoids that have been well-known for some time as potent antioxidants that promote blood vessel strength and optimal eye health. More recently, however, researchers have discovered two new roles for OPCs: lowering blood pressure and cholesterol.

Grape seed extract for high cholesterol

Oxidized LDL particles play a key role in the formation of arterial plaques and the development of atherosclerosis. Grape seed extract decreased oxidized LDL particles in addition to lowering total and LDL cholesterol in a recent randomized double-blind placebo-controlled study.[1] Fifty-two individuals with mildly high cholesterol were divided into two groups that received either 200 mg/day of grape seed extract or placebo for 8 weeks. The grape seed extract significantly reduced total cholesterol by an average of 10.7 mg/dL, LDL cholesterol by an average of 9.7 mg/dL, and oxidized LDL by an average of 5.5 mg/dL. While triglyceride and very low-density lipoprotein cholesterol were decreased and high-density lipoprotein cholesterol was increased by the grape seed extract, the changes were not statistically significant. The study authors concluded that grape seed extract lowers the risk of atherosclerosis and cardiovascular disorders in people with mild cholesterol abnormalities.

Grape seed extract for high blood pressure

When taken as a supplement, grape seed extract has also been shown to significantly lower blood pressure, in some small studies. Two studies performed at the University of California Davis, one in people with metabolic syndrome and one in people with prehypertension, both found that grape seed extract lowers both systolic (the top number) and diastolic (the bottom number) blood pressure. In the first study, 300 mg per day of grape seed extract (MegaNatural BP by Polyphenolics—a patented extract) lowered both the systolic and diastolic blood pressures compared to placebo in subjects with metabolic syndrome.[2] Those in the grape seed extract group experienced average blood pressure reductions of 12 mmHg systolic and 8 mmHg diastolic while those in the placebo group saw no changes. The grape seed extract also decreased the oxidation of LDL particles, lowering the subjects’ risk of atherosclerosis. In the second study, 32 participants with prehypertension (systolic blood pressure of 120-139 mmHg or a diastolic blood pressure of 80-89 mmHg) were randomly assigned to receive grape seed extract (300 mg per day) or placebo for eight weeks.[3] Participants who took the grape seed extract reduced their systolic blood pressure by an average of 8 mmHg and diastolic blood pressure by 5 mmHg. The blood pressure of those in the placebo group did not change.

How to take grape seed extract as a supplement to lower high blood pressure and cholesterol

Grape seed extract is one of the most powerful antioxidants yet discovered. To take advantage of this natural compound for lowering blood pressure and cholesterol, look for grape (vitis vinifera) seed extract, standardized to contain at least 92%-95% polyphenols (including OPCs). Take 300 mg once a day or split the dose. Take the supplement for a full 12 weeks to get optimal results. Grape seed extract is not associated with side effects and there are no reported interactions between grape seed extract and any medications or supplements. Tell us your favorite uses of grape seed extract in your family

Grape seed extract comes in liquid tincture form or in capsules, and it has literally dozens of uses around your home in addition to its blood pressure and cholesterol benefits. These include such uses as wrinkle and sagging skin improvement, a natural anti-histamine, and eye health restorer. Share in the comments section below how you use grape seed extract and what form (liquid or capsule) is your favorite.

6 Oils That Work 10 Times Better Than Any Body Lotion By: Kumutha Published

Source:http://www.boldsky.com/beauty/body-care/2016/six-oils-that-work-ten-times-better-than-body-lotion-105432.html

(Kumutha)

At some point or the other, we all have faced this dilemma, "which is the better option" natural body oil or a body lotion? Both body lotion and natural oil do the same job of moisturisingyour skin, so what difference does it make? A HUGE difference apparently. Lotion is basically a combination of oil and water, since oil and wax do not combine well, wax is used to emulsify the ingredients. The wax forms a layer on the skin, which helps trap the moisture. Only downfall is, the layer does not just trap moisture, but also dirt and bacteria, which clog pores, leading to breakout.

Furthermore, this layer is like a barrier on the skin, which prevents the nutrients in the oil from getting absorbed by the skin. Ayurvedic or natural body oil, on the other hand, is a powerhouse of essential vitamins, fatty acids and antioxidants. And it is 100% active, which means it easily gets absorbed by the skin, without creating any filters. And on the contrary to the popular belief, herbal oils do not disrupt the natural balance of your skin, in fact they help control the sebaceous glands, keeping oil production in check! So, here are 6 herbal oils that work better than any body lotion, take a look!

Coconut Oil

Let's see what coconut oil does, shall we? It is a potent moisturizer that works well as a non-toxic eye makeup remover and is a great alternative to shaving cream! But why should you use coconut oil instead of a body lotion? Well, it is a powerhouse of antibacterial and antiseptic properties, is rich in antioxidants and vital vitamins, all of which nourish, hydrate and clear the skin!

Jasmine + Camelia + Grapeseed oil

Camelia is high on omega-6 and omega-9 acids, which boost the skin's elasticity and promote healthy glow. Grapeseed oil has linoleic acid and vitamins that tone and tighten the skin, whereas jasmine will make you smell incredible and has antioxidants, which will keep your skin healthy.

-How It Works • Mix all the moisturising oils for dry skin in an equal quantity, and store it in an air-tight bottle. • Depending on the requirement, use it sparingly.

Jojoba + Chia Seed + Almond Oil

Almond oil is packed with antioxidants that repair the damaged skin cells and promote skin regeneration. Jojoba oil has moisture balance close to the sebum of our skin, which makes it easily absorbable. And, chia seed oil has a high count of omega, which soothes skin inflammation.

-How It Works • Mix 1 teaspoon of almond oil, with 10 drops of jojoba oil and chia seed oil. • After shower, massage the Ayurvedicbody oil onto your skin. • Depending on your skin's natural moisture, tweak the amount.

Lavender + Citrus + Lemongrass + Avocado Oil

Ideal to soothe aching muscles,Lavender has linalool, which lightens scar. Citrus oil has vitamin C that rejuvenates the skin. Avocado is a powerhouse of vitamins and antioxidants, which tighten skin, hydrating from within and promoting skin regeneration. And lemon grass oil gives the concoction a light and healing fragrance.

-How It Works • Mix 1 tablespoon of avocado oil, with 10 drops of lavender, 5 drops of citrus and 2 drops lemon grass oil. • Massage your skin with thisnatural body oil and feel your muscles getting relaxed to a great extent.

Shea Butter + Grapeseed Oil

Shea butter has an ample amount of vitamin A, which hydrates the skin by penetrating deep while removing dark patches and lightening scars. And grapeseed oil has vitamin C, which lightens and brightens the skin.

-How It Works • In a low flame, melt shea butter, and stir in 10 drops of grapeseed oil. • Turn off the flame, once shea butter melts, allow it to cool in room temperature. • Massage the natural body oil onto the skin after every shower.

Olive Oil + Argan + Sandalwood Oil

Olive oil has a high ratio of antioxidants that hydrate and repair damaged skin cells. Vitamin E, present in argan oil, lightens and tightens the skin Sandalwood oil gives the concoction an amazing fragrance, plus it soothes inflammation.

-How It Works • Mix 10 drops of olive oil, with 5 drops of arganoil and 5 drops of sandalwood oil. • Massage the mixture onto your skin every day, and watch your skin become visibly softer and smoother in 10days!

Lower heart disease, diabetes risk with grapeseed oil

Source:http://www.firstpost.com/living/lower-heart-disease-diabetes-risk-with-grapeseed-oil-2660858.html

(IANS)

New York: A diet rich in a fatty acid that is essential for nutrition and found in grapeseed and other oils but not in olive oil may lower the risk of heart disease and diabetes, suggests a study.

The results showed that men and women with higher linoleic acid levels -- which contains omega-6 fatty acid -- are less prone to heart disease and inflammation and also possess more lean body mass.

Higher linoleic acid levels also means lower likelihood of insulin resistance, which is a precursor to diabetes.

“This finding could have obvious implications in preventing heart disease and diabetes, but also could be important for older adults because higher lean body mass can contribute to a longer life with more independence,” said Martha Belury, professor at Ohio State University.

Grapeseed oil for now remains an excellent source of linoleic acid, which constitutes about 80 percent of its fatty acids. Corn oil also remains a decent source, the researchers noted.

However, the general consumption of linoleic acid is declining because of genetic modification of plants for food manufacturers seeking oils higher in oleic acid. The industry's push against trans fats can be one possible reason.

"Vegetable oils have changed. They're no longer high in linoleic acid," Belury pointed out.

When linoleic acid gets solid (hydrogenated) for processed foods, it is more likely to convert to trans fat than its oleic cousin.

So oils, notably safflower, sunflower and soybean, now routinely contain less linoleic acid - it often makes up less than 20 percent of the fatty acids in commonly purchased oils, based on food labels and confirmed by testing in her lab, Belury explained.

The study, published in the journal Molecular Nutrition & Food Research, is the first to examine linoleic acid alongside body composition and other health markers in people who hadn't been given supplements or prescriptive diets, the researchers noted.

Grapeseed Oil Benefits: Actually Healthy or a Big, Fat Lie?

Source:http://food.ndtv.com/health/grapeseed-oil-benefits-actually-healthy-or-a-big-fat-lie-1403072

By Aashna Ahuja (NDTV)

A few days go by and a new “health food” arrives in the market. In plenty cases, the health claims are spurious and don’t have any real studies to support them. The same appears to be the case with grapeseed oil, a leftover by-product of wine-making. Grapeseed oil is a polyunsaturated oil that is chemically extracted from the seeds of grapes after wine is made.

The 5 “Benefits” of Grapeseed Oil

Grapeseed oil benefits are based on the supposedly high amounts of nutrients, antioxidants and polyunsaturated fats of the seeds. But here’s a newsflash… most of the nutrients and antioxidants (including the proanthocyanidins) from grape seeds are not present in the oil. Let’s take a look at the supposed benefits of using grapeseed oil.

1. Grapeseed oil is a good source of Vitamin E

After the intense chemical extraction process, most of the good properties are actually filtered out. The only nutrient left in any significant amount is Vitamin E. One tablespoon of grapeseed oil contains 9 mg of Vitamin E, which is 19% of the Recommended Daily Allowance. In fact, grapeseed oil contains about twice as much Vitamin E as olive oil. Vitamin E is an antioxidant that helps prevent cell damage in your body and strengthens your immune system.

2. Grapeseed oil has no cholesterol and very little saturated fat

Yes, grapeseed oil is rich in cholesterol-lowering polyunsaturated fats. 1 tablespoon of grapeseed oil contains 14 grams fat, about 10 percent of which is saturated fat, 16 percent monounsaturated and 70 percent polyunsaturated.

3. Grapeseed oil has a high smoke point

It’s true. The Academy of Nutrition and Dietetics notes that grapeseed oil has a moderately high smoking point which makes it ideal for frying and sauteing. “Grapeseed oil has a mild nutty taste so the flavour of the food you are cooking with it shine through. For Indian food, you can make your dry vegetable preparations with grapeseed oil”, says Delhi-based Nutritionist Anshul Jaibharat. It also has terrific emulsifying properties, which makes it an excellent oil for salad dressings.

4. Grapeseed oil has the highest concentration of polyunsaturated fats, so it’s good for your heart

Yes, grape seed oil is very high in polyunsaturated fats. However, there are two main kinds of polyunsaturated fats: Omega-3s and Omega-6s. To maintain optimal health, the balance of different kinds of polyunsaturated fats is important. And as it turns out, grapeseed oil contains mostly Omega-6 fatty acids. According to Dr. Rupali Datta, SmartCooky, “Indian diets do not need such a high amount of Omega-6”. There is also not enough scientific backing to prove that grapeseed oil is heart healthy.

5. Grapeseed oil is beneficial for hair and skin

Grapeseed oil has been championed as a wonderful addition to any beauty regimen, and for good reason. Dr. Ashutosh Gautam, Clinical Operations and Coordination Manager at Baidyanath says, “Grapeseed oil helps remove tan, moisturise the skin, give you that glow you’ve always wanted and even lighten the effects on age spots. Many skincare creams contain grapeseed oil as well”. It contains 73% of linoleic acid which may be beneficial in the treatment of acne, allergic reactions and dry and itchy skin. Grapeseed oil is free from synthetic ingredients and loaded with moisturising fatty acids, so there seems to be nothing wrong with applying it topically.

The Bottom Line?

Shilpa Arora says, “I’m not a fan of grapeseed oil. It may be good if used in moderation. But in larger quantities, it may inhibit the absorption of other nutrients”. Grapeseed oil lacks in vitamin K, vitamin C, copper and potassium in comparison to actually eating grapes. Dr. Rupali Datta, Chief-Nutritionist, SmartCooky says, “There is very little scientific evidence that supports grapeseed oil being healthy. However, given its nutritional profile, it seems safe for consumption. You can use this oil in combination with other cooking oils”. So it should not be the primary source of fat in your diet. Nutitionist Anshul agrees, “Since no one oil has everything, you can use a combination of two-three oils in a month. If you like the taste of grapeseed oil, aim to balance it out with other types of healthy fats from coconut oil and olive oil”.

Grapeseed extract shows promise in prevention of cancer

Source:http://www.dailyherald.com/article/20151115/entlife/151119636/

By Patrick B. Massey, MD, PH.D.

Albert Einstein once said "Look deep into nature, and then you will understand everything better."

In regards to the prevention and treatment of cancer, we are discovering that the foods we eat may have significant impact. A case in point is grapeseed extract.

Over the past 10 years, a number of medical studies have demonstrated that grapeseed extract, at least in animal models, can have significant impact on a number of different cancers. Although there are no compelling human clinical studies, grapeseed extract in the animal models of cancer are quite positive.

Grapeseed extract, as the name implies, comes from grapeseed. This particular product is very rich in a number of vitamins, as well as other biologically active compounds such as flavonoids, procyanidins and resveratrol.

Although most of the research into grapeseed extract has been done in animal models, grapeseed extract seems to have a positive effect throughout the entire body.

For example, in animals it has been shown to increase bone density. There is some data indicating that it also is effective at preventing tooth decay and reducing blood pressure. It does exhibit some antibacterial and antiviral activity in a test tube.

Most importantly, grapeseed extract seems to retard cancer cell growth both in the test tube and in animal models. A number of studies over the years have demonstrated that it inhibits the growth of cancer cell lines of lung, breast, prostate and colon cancers.

Some of the most interesting anticancer research has explored the aromatase-inhibiting activity of grapeseed extract and its effect on breast cancer cell growth. One older study published in 2006 demonstrated that grapeseed extract has significant aromatase-inhibiting activity and suppresses the growth of breast cancer cells in the mouse model for breast cancer.

Aromatase is an enzyme that, basically, converts testosterone into estrogen. Many types of breast cancer are stimulated by estrogen and have a very active aromatase enzyme system.

In traditional medicine some chemotherapy agents inhibit the activity of the aromatase enzyme and through that inhibition slow or prevent the growth of estrogen-sensitive breast cancer cells.

This 2006 study, published in Cancer Research, demonstrated that grapeseed extract has significant aromatase-inhibiting activity and greatly reduced the growth of breast cancer cells in mice that are genetically designed to develop breast cancer.

Since this study was published, dozens of other studies have demonstrated that many plants inhibit aromatase activity and may be beneficial for the prevention and treatment of a number of different cancers including breast cancer, colon cancer and prostate cancer.

Even though grapeseed extract may inhibit the growth of breast cancer cells, I do not endorse it as sole treatment for breast cancer.

In addition, there is always concern as to how grapeseed extract affects medications, even though the current data indicates that it is quite safe. A medical physician, board-certified in integrative medicine would be able to provide the best recommendations for the use of grapeseed extract during chemotherapy.

7 Amazing Benefits of Grapes for Health and Skin

Source:http://food.ndtv.com/food-drinks/benefits-of-grapes-from-being-a-powerful-antioxidant-to-preventing-signs-of-ageing-1223636

By Plavaneeta Borah

From being used in dishing out sinful desserts and refreshing fruit bowls to being renowned as the primary ingredient in the wine making process, it is not without reason that grapes are known as the queen of fruits. Classified under the family of berries, grapes come in different varieties as well as colours – green, red, blue, purple and black. While majority of the production of grapes in the world are used by the wine making industry, the remaining lot is consumed as fruits and a small portion is used in making dried fruits.

Tracing its roots, it is said that grapes were first domestically cultivated in the Middle East, where it soon became popular when the city of Shiraz started using it to make wine. Eventually, other countries also started growing it and using it in the wine making process.

Grapes are easily available in the markets throughout the year. The vine containing the cluster of berries are not only pretty to look at and delicious with its sweet and tarty taste, but are loaded with essential nutrients that work for the well-being of the body.

Why Grapes are Good for You?

Researchers and many studies have found that including grapes in one’s diet can actually be good for health as it has numerous health benefiting properties –

1. Loaded with Antioxidants

Grapes are a powerhouse of antioxidants – they contain a wide range of phytonutrients right from carotenoids to polyphenols. Studies have revealed that these phytonutrients help in preventing certain kinds of cancers and help in maintaining heart health. Among polyphenols, resveratrol is known for its miraculous properties such as inhibiting the formation of free radicals that could cause cancer and dilating blood vessels to ease blood flow and lower blood pressure. Point to note: The antioxidant content is the highest in the seeds and the skin. So, do make use of them.

2. Prevents Skin Problems

It is found that resveratrol prevents signs of ageing and other skin problems. According to a study conducted by the team at the University of California, Los Angeles (UCLA), resveratrol, when combined with a common acne medication benzoyl peroxide, fights the acne causing bacteria.

3. High Source of Potassium

The nutritional breakup of grapes reveals that per 100 grams of the fruit contains 191 mg of potassium. High intake of potassium and lowering sodium content can help your body in numerous ways. Potassium also counteracts excess sodium. A low-sodium-high-potassium diet has proven beneficial for high blood pressure, high cholesterol and heart health in most cases. According to Robynne Chutkan, a gastroenterologist, author and founder of the Digestive Centre for Women in Washington D.C., a bloated stomach can invite many health-related problems. Cutting down on salt intake and focusing on potassium-rich fiber can help in getting a flat stomach.

4. Good for the Eyes

According to a study done by University of Miami, Florida, grapes promote eye health from signalling changes at the cellular level to directly countering oxidative stress. Including grapes in the diet results in lower levels of inflammatory proteins and higher amounts of protective proteins in the retinas, which is the part of the eye that contains the cells that respond to light, known as photoreceptors.

5. Boost Brain Power

Certain studies have found that resveratrol helps in increasing blood flow to the brain, thereby it could help speed up mental responses and prove to be beneficial for those suffering from brain related ailments like Alzheimer’s. A study done by the University of Switzerland also found that resveratrol can help remove plaques and free radicals, which affect the brain.

6. Good for the Knees

A study done by Texas Woman's University has established that daily intake of grapes can help get relief from knee pain, especially the ones triggered due to symptomatic osteoarthritis. Grapes are high on antioxidants, most important and beneficial one being polyphenols, which help in improving the flexibility and mobility of joints.

7. Anti-Inflammatory Properties

It has been found that grapes contain certain enzymes which bring about anti-inflammatory effect in our body. As such it brings about relief to the arteries, promotes heart health and helps in other repair functions of the body.

How to Include Grapes in Your Diet

Besides all the health benefits, grapes are also loaded with vitamins and essential minerals such as Vitamins A, B-6, B-12, C and D, calcium, iron and magnesium. However, one shouldn’t overload on grapes as they also contain sugar. It is said that berries should be included at least 3-4 days in a person’s weekly diet plan. And one should always consume a mix of fruits for better benefits. Although if you are consuming only grapes alone, then the serving per day could be 2-3 cups, considering each cup contains about 15-20 grapes.

Cooking with Grapes

The juicy flesh and the sweet and tarty flavour make this fruit an ideal ingredient to cook with. Enjoy them whole by adding them to fruit bowls and summer salads. Try and get your hands on the different coloured grapes (blue and red) to add some drama to your dish. Team them with pearl barley, lettuce, chopped cucumber, capsicum – choices are aplenty!

Coming to baking, you can use them to make berry tarts and clafoutis, top them on pavlovas or pannacottas, roast them along with chicken, or make tea cakes. You could also use them to make sweet and spicy chutneys, compotes and sauces; shake up some refreshing mocktails; or even use them to make sorbets.

Here are some recipes to get you started –

1. Grape Chicken

A simple but delicious recipe of chicken cooked with pureed grapes and served with a sauce of chicken stock and grape juice.

For the recipe, click here.

2. Angoor Rabdi

Rich, creamy and smooth, this version of the classic Indian dessert is made with grapes. Easy to prepare at home, this dessert is sure to be a big hit.

For the recipe, click here.

3. Carrot Salad with Black Grape Dressing

Why buy salad dressings off the rack that are full of preservatives? Here's how you can whip up a quick carrot salad with raisins and almonds and a lipsmacking black grape dressing.

For the recipe, click here.

Grapeseed Oil May Reduce Heart Disease, Diabetes Risks

Source:http://www.techtimes.com/articles/139405/20160309/grapeseed-oil-may-reduce-heart-disease-diabetes-risks.htm

By Katherine Derla (Tech Times)

Grape seed extract is an industrial derivative of grape seeds, extremely rich in antioxidants and oligomeric proanthocyanidin complexes (OPCs).

The extract has been linked to a wide range of possible therapeutic properties including healing wounds and treating conditions such as high cholesterol, atherosclerosis, macular degeneration, poor circulation, nerve damage, as well as preventing cancer.

Although many of these health claims are still not completely backed up by "high quality" studies, strong evidence is beginning to emerge on grape seed extract's extensive health benefits.

Grape seed extract is available as a dietary supplement in either a liquid form, tablets or capsules. Supplements generally contain between 50 to 100 mg of the extract.

This Medical News Today information article provides details on the benefits of grape seed extract as well as side effects and precautions associated with its use.

What are the benefits of grape seed extract

Studies on animal models have revealed that the extract can be effective in treating heart diseases. Some experts think that grape seed extract could even have anticancer and cancer chemopreventive potential.

Over recent years there has been a great deal of research pointing to key therapeutic properties of the grape seed extract. Listed below are some of the key findings.

Health benefits associated with grape seed extract:

•Healing wounds - Grape seed extract can heal dermal wounds.

A study, published in the journal Free Radical Biology and Medicine, "provided firm evidence to support that topical application of GSPE represents a feasible and productive approach to support dermal wound healing."

•Improving bone strength - Including grape seed extract in your diet with calcium has a "beneficial effect on bone formation and bone strength for the treatment of bone debility caused by a low level of calcium," according to research published in the Journal of Musculoskeletal & Neuronal Interactions.

•Preventing skin cancer - Grape seeds contain proanthocyanidins which can prevent the development of cancer.

A study, published in the journal Molecular Nutrition & Food Research, found that grape seeds have properties that can reduce the severity of skin cancer. The researchers concluded that grape seed extracts "could be useful in the attenuation of the adverse UV-induced health effects in human skin."

•Cardiovascular benefits - The antioxidants in grape seed extract can potentially protect the blood vessels from becoming damaged, which may prevent high blood pressure.

According to one study, published in the journal Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, "grape seed proanthocyanidin extract (GSPE) provides superior antioxidant efficacy as compared to Vitamins C, E and β-carotene."

•Reducing edema (swelling) - Taking grape seed extract can help reduce the swelling that occurs after an injury or surgery.

A double-blind, placebo-controlled study found that breast cancer patients who took 600 mg of grape seed extract every day for 6 months had less edema compared to those on placebo.

•Preventing cognitive decline - Grape seed extract is very high in proanthocyanidins (oligomers of monomeric polyphenols) which may prevent cognitive decline.

One study identified "a critical role for grape seed proanthocyanidin extract (GSPE) as a neuroprotectant in the hippocampus and in preventing cognitive loss with aging."

8 Amazing Benefits of Grapes

Source:http://www.nigeriatoday.ng/2016/06/8-amazing-benefits-of-grapes-5-refreshing-recipes/

(Nigeria Today)

A healthy and well-balanced diet is key to living life to the fullest. Amidst our busy lives; however, none of us really take the time to think about what we use to fuel our bodies. Are we eating the right kinds of food to get us through the day? Are we filling ourselves with the proper nutrients? For the majority of us, we probably aren’t. Fortunately, we can solve this problem one baby step at a time, starting with a step as simple as eating a few grapes a day.

Grapes, you ask? Is that it?

Well, no, it will not solve all of your diet problem. However, striving towards a healthy lifestyle begins with healthy eating. It is not so commonly known that in terms of nutritional value, grapes are some of the most delicious, nutritious, and versatile fruits you can come across.

For those who have not already been enlightened with the extensive health benefits of grapes, here are a few reasons you may want to throw a few in your shopping basket during your next grocery shop.

1.) Aids the treatment of acne

An antioxidant derived from grapes known as resveratrol can prevent the growth of acne-causing bacteria. According to experts, the antioxidant in grapes, combined with prescribed treatments for acne such as benzyl peroxide, can provide effective treatment against acne.

2.) Promotes a healthy digestive system

The abundant presence of fiber and nutrients in grapes allow them to promote a healthy digestive system, assisting in the prevention of constipation and indigestion. A healthy intake of fiber promotes healthy bowel movement. For those lacking in daily fiber intake, grapes are a delicious and low GI way to fill those fiber needs.

3.) Grape seed extract

Grape seed extract (an industrial derivative of grape seeds) is abundant in therapeutic properties, such as the treatment of high cholesterol and the prevention of cancer. The inclusion of grape seed extract, as well as calcium, can improve bone strength and assist in the treatment of bone weakness from low calcium levels.

4.) Assists with management of asthma

A healthy and nutrient-filled diet has been proven to assist with the management of asthma. Studies show that children with a high consumption of fruits (such as grapes) are less likely to have asthma-like symptoms. A component in grape seed extract contains anti-inflammatory properties. Additionally, studies have also shown that grape seed extract improves lung function and increases lung capacity.

5.) Assists with management of diabetes

An extract derived from the skin of grapes (grape skin extract) can be developed and used to aid the management of diabetes. Studies also show that the low GI nature of grapes and grape products can provide health benefits for individuals suffering type-2 diabetes. Due to their high nutritional content and low calorie count, professionals recommend red and black grapes for diabetics.

6.) Lowers the risk of heart disease

Studies suggest that the consumption of grapes or other polyphenols (abundant micronutrients) is associated with a lower risk of heart disease. Grapes contain an extensive variety of polyphenol compounds (such as resveratrol). Daily intake of these nutrients assists with cardiovascular health.

7.) Cancer prevention and longevity

Grapes contain powerful natural chemicals which provide a variety of everyday health benefits, and are even known to assist in the slowing or prevention of cancer. According to studies, these chemicals have the potential to stop the spread of cancer cells. It is also believed that several grape phytonutrients play a role in an individual’s longevity.

8.) Helps protect eyesight

Not only do grapes aid in the prevention of cancer and treatment of diabetes, they are also beneficial for healthy eyesight. Research suggests that regular grape consumption protects retinal structure and function, as well as preventing retinal deterioration.

The Benefits of Grape Seed Extract

Source:http://www.huffingtonpost.com/livestrongcom/the-benefits-of-grape-see_b_646688.html

By Shelley Moore (LIVESTRONG.COM)

Grape seeds contain potent antioxidants, which are substances that neutralize and eliminate harmful free radicals. Some research, primarily with animals, indicates that standardized grape seed extracts may be useful for treating health problems related to free radical damage, according to the the University of Maryland Medical Center (UMMC). The UMMC advises using herbal therapy under the supervision of a health care provider qualified in botanical medicine.

Antioxidants

Vitamin E is an important antioxidant in grape seed, but even more powerful are the flavonoids called oligomeric proanthocyanidin complexes, or OPCs, according to the UMMC. Antioxidants destroy free radicals, which are waste products that develop from the conversion of food to energy and also occur in response to environmental toxins. Free radicals damage cells and genetic material and may contribute to aging and disease, including heart disease and cancer.

Blood Vessel Benefits

Evidence indicates a substantial health benefit for patients with chronic venous insufficiency who take grape seed extract, according to the University of Michigan Health System (UMHS). This disorder causes blood to pool in leg veins, leading to leg swelling and fatigue, as well as pain that worsens when walking. Grape seed extract also may be beneficial for treating varicose veins and capillary fragility, although research is not as consistent, notes the UMHS.

Additionally, the antioxidants in grape seed have a protective effect on blood vessels, which can help prevent high blood pressure. Animal research indicates that grape seed extract lowers blood pressure, according to the UMMC, but research on humans is lacking.

Anti-Cancer Effects

Grape seed antioxidants also may decrease the risk of developing cancer. Additionally, laboratory studies show that grape seed extract prevents the growth of various types of cancer in test tubes, according to the UMMC, including breast, colon, stomach, prostate and lung cancer. Grape seed extract also may protect the liver from cell damage caused by chemotherapy.

Side Effects

Grape seed extract is generally not associated with side effects, according to the UMHS, and excess is removed through urine. The most likely side effects include headache, dizziness, nausea and a dry, itchy scalp, according to the National Center for Complementary and Alternative Medicine. Grape seed extract may have blood-thinning properties, which could increase the risk of bleeding if taken with blood thinning medications.

Usage

Grape seed is available as liquid extract and dried extract in capsules and tablets. The UMMC recommends buying extracts standardized to at least 40 percent proanthocyanidins or at least 95 percent OPCs. To protect against free radical damage, take 25 to 150mg one to three times daily, and for chronic venous insufficiency, take 150 to 300mg once per day. The UMMC advises that children as well as pregnant or breastfeeding women should not take grape seed supplements.

Grapeseed extract shows promise in prevention of cancer

Source:http://www.techtimes.com/articles/139405/20160309/grapeseed-oil-may-reduce-heart-disease-diabetes-risks.htm

By Patrick B. Massey (MD, PH.D.)