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Difference between revisions of "Milk Thistle"
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:• Cream Cleanser – a cleanser that is not overly harsh or drying can help keep the skin stable and reduce the risk of irritation. | :• Cream Cleanser – a cleanser that is not overly harsh or drying can help keep the skin stable and reduce the risk of irritation. | ||
:• Moisturizer Containing Sunblock – The American Academy of Dermatology recommends daily use of a sunscreen with a sun protection factor (SPF) of at least 15 that protects against both UVA and UVB rays. Makeup or foundations containing sunscreen often are not applied thickly or evenly enough to provide adequate protection. | |||
:• Anti-Aging Product at Night – Active ingredients to look for in an anti-aging cream include glycolic, ascorbic, or retinoic acid. Alster recommends using one or two of these products on an alternate night basis to help skin turnover more regularly. However, some anti-aging creams may increase skin sensitivity. | :• Anti-Aging Product at Night – Active ingredients to look for in an anti-aging cream include glycolic, ascorbic, or retinoic acid. Alster recommends using one or two of these products on an alternate night basis to help skin turnover more regularly. However, some anti-aging creams may increase skin sensitivity. | ||
Revision as of 03:14, 19 February 2016
Herbal Remedies and Medicinal Cures for Diseases, Ailments & Illnesses that afflict Humans and Animals
Aloe Vera •
Astragalus •
Bankoro •
Bilberry •
Bitter Gourd (Ampalaya) •
Bitter Orange •
Black Cohosh •
Cat's Claw •
Chamomile •
Chasteberry •
Coconut •
Cranberry •
Dandelion •
Echinacea •
Ephedra •
European Elder Tree •
Evening Primrose •
Fenugreek •
Feverfew •
Flaxseed •
Garlic •
Ginger •
Ginkgo •
Ginseng (Asian) •
Golden Seal •
Grape Seed •
Green Tea •
Hawthorn •
Hoodia •
Horse Chestnut •
Kava •
Lavender •
Licorice •
Malunggay Moringa Oleifera •
Milk Thistle •
Mistletoe •
Passion Flower •
Peppermint Oil •
Red Clover •
Ringworm Bush (Akapulko) – Cassia alata •
Saw Palmetto •
St. John's Wort •
Tawa Tawa •
Turmeric •
Valerian •
Yohimbe •
accept the bitter to get better
Milk Thistle Flower | |||
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Milk Thistle Flower | |||
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Milk Thistle
This fact sheet provides basic information about milk thistle—common names, what the science says, potential side effects and cautions, and resources for more information.
Milk thistle is a flowering herb native to the Mediterranean region. It has been used for thousands of years as a remedy for a variety of ailments, and historically was thought to have protective effects on the liver and improve its function. Today, its primary folk uses include liver disorders such as cirrhosis and chronic hepatitis, and gallbladder disorders. Other folk uses include lowering cholesterol levels, reducing insulin resistance in people who have both type 2 diabetes and cirrhosis, and reducing the growth of breast, cervical, and prostate cancer cells.
Silymarin, which can be extracted from the seeds (fruit) of the milk thistle plant, is believed to be the biologically active part of the herb. The seeds are used to prepare capsules, extracts, powders, and tinctures.
Latin Name--Silybum marianum
- information from NCCAM verbatim
- Milk thistle (Silybum marianus) is regarded as one of the most important herbal liver tonics and restoratives. As is the case with Feverfew, medical use of Milk thistle may be traced back more than 2,000 years. Like Feverfew, Milk thistle has been subject to many clinical trials which clearly demonstrate its effectiveness. It is frequently recommended to counteract the harmful effects of alcohol and other drugs on the liver and clinical studies have shown that it helps the liver to return to normal functioning once drinking has stopped. Scientific analysis of Milk thistle shows that it contains a flavonoid complex called silymarin, which is largely responsible for the medical benefits of this herb. Silymarin is a powerful anti-oxidant and can block the entrance of toxins into the liver and remove toxins at a cellular level, thereby resulting in regeneration of liver cells and improved liver functioning. This would have a direct impact on overall systemic health as the liver is one of the most important organs in the body.
What Milk thistle Is Used For
- Milk thistle is believed to have protective effects on the liver and improve its function. It is typically used as an herbal remedy to treat liver cirrhosis, chronic hepatitis (liver inflammation), and gallbladder disorders.
- Treatment claims also include:
- Lowering cholesterol levels
- Reducing insulin resistance in people with type 2 diabetes who also have cirrhosis
- Reducing the growth of cancer cells in breast, cervical, and prostate cancers
Herbal Remedy Products with Milk thistle as part of the ingredients
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How Milk thistle Is Used
Milk thistle is a flowering herb. Silymarin, which can be extracted from the seeds (fruit), is believed to be the biologically active part of the herb. The seeds are used to prepare capsules containing powdered herb or seed; extracts; and infusions (strong teas).
What the Science Says about Milk thistle
- There have been some studies of milk thistle on liver disease in humans, but these have been small. Some promising data have been reported, but study results at this time are mixed.
- Although some studies conducted outside the United States support claims of oral milk thistle to improve liver function, there have been flaws in study design and reporting. To date, there is no conclusive evidence to prove its claimed uses.
- NCCAM is supporting a phase II research study to better understand the use of milk thistle for chronic hepatitis C. With the National Institute of Diabetes and Digestive and Kidney Diseases, NCCAM is planning further studies of milk thistle for chronic hepatitis C and nonalcoholic steatohepatitis (liver disease that occurs in people who drink little or no alcohol).
- The National Cancer Institute and the National Institute of Nursing Research are also studying milk thistle, for cancer prevention and to treat complications in HIV patients.
Previous laboratory studies suggested that milk thistle may benefit the liver by protecting and promoting the growth of liver cells, fighting oxidation (a chemical process that can damage cells), and inhibiting inflammation. However, results from small clinical trials of milk thistle for liver diseases have been mixed, and two rigorously designed studies found no benefit.
A 2012 clinical trial, cofunded by NCCAM and the National Institute of Diabetes and Digestive and Kidney Diseases, showed that two higher-than-usual doses of silymarin were no better than placebo for chronic hepatitis C in people who had not responded to standard antiviral treatment.
The 2008 Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) study, sponsored by the National Institutes of Health (NIH), found that hepatitis C patients who used silymarin had fewer and milder symptoms of liver disease and somewhat better quality of life but no change in virus activity or liver inflammation.
Side Effects and Cautions of Milk thistle
- In clinical trials, milk thistle generally has few side effects. Occasionally, people report a laxative effect, upset stomach, diarrhea, and bloating.
- Milk thistle can produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy).
- It is important to inform your health care providers about any herb or dietary supplement you are using, including milk thistle. This helps to ensure safe and coordinated care.
News About Milk Thistle
Milk Thistle: A Liver and Skin Protector
- By Nicole Cutler
Supplementing with milk thistle offers more than one benefit. It protects liver cells on the body’s inside and skin cells on the outside.
Milk thistle is well known to protect liver cells from damaging toxins. Despite milk thistle’s frequent association with liver cell protection, the liver is not the only beneficiary of this popular supplement. Some relatively new studies have determined that the skin receives a similar protective benefit from milk thistle as the liver does. Liver Protection
The human liver is capable of recovering from an injury, but chronic liver disease repeatedly challenges this ability. When the rate of liver cell injury outpaces the liver’s regenerative capacity, scars form. Unfortunately, scarring in the liver can block blood flow – a problem that fosters even more damage to liver tissue. If this damaging cycle persists, severe scarring can render the liver no longer capable of performing all its duties. Thus, those who either have liver scarring or are at high risk of liver damage due to fat accumulation, hepatitis, excessive exposure to alcohol or toxins, or another liver disadvantage are encouraged to take action against further liver injury.
Milk thistle seed extract has been used for centuries to add a layer of protection to vulnerable liver cells. Experts have found that milk thistle:
- • Strengthens the outer walls of liver cells to better resist injury
- • Promotes the growth of healthy liver cells
- • Fights oxidation – a process that damages liver cells
Decades of clinical trials indicate that silymarins, a group of potent antioxidants extracted from the seeds of milk thistle, are responsible for milk thistle’s therapeutic properties. Of the silymarins, silybin (also referred to as silibinin) has been shown to be the most effective constituent of silymarin for preserving liver health. External Skin Protection
Guarding against ultraviolet radiation is the primary concern for keeping the skin healthy. To shield the skin from damage, the U.S. Centers for Disease Control and Prevention (CDC) suggest:
- • seeking shade during the midday hours
- • wearing clothing over exposed skin
- • donning a wide-brimmed hat
- • wearing UVA and UVB blocking sunglasses
- • applying sunscreen
- • avoiding indoor tanning
Most recommended skin protectors come in the form of soaps, lotions or creams designed to keep skin clean and moist while deflecting harmful radiation. According to Tina Alster, MD, clinical professor of dermatology at Georgetown University, a regimen including the following topical products helps protect the skin:
- • Cream Cleanser – a cleanser that is not overly harsh or drying can help keep the skin stable and reduce the risk of irritation.
- • Moisturizer Containing Sunblock – The American Academy of Dermatology recommends daily use of a sunscreen with a sun protection factor (SPF) of at least 15 that protects against both UVA and UVB rays. Makeup or foundations containing sunscreen often are not applied thickly or evenly enough to provide adequate protection.
- • Anti-Aging Product at Night – Active ingredients to look for in an anti-aging cream include glycolic, ascorbic, or retinoic acid. Alster recommends using one or two of these products on an alternate night basis to help skin turnover more regularly. However, some anti-aging creams may increase skin sensitivity.
- Internal Skin Protection
Skin is traditionally protected with topical creams or lotions, but researchers have found a non-traditional method that protects against skin damage as well. In addition to protecting liver cells, internal supplementation with milk thistle also seems to protect skin cells.
As published in the January 2013 edition of the journal Molecular Carcinogenesis, researchers from the University of Colorado Cancer Center found that silibinin:
- • protects against skin cancer-causing ultraviolet-B (UVB) radiation by upping cell expression of a particular cell-repairing protein
- • kills cells that have undergone mutations due to ultraviolet-A (UVA) radiation (a process that potentially leads to skin cancer)
These results support previous findings that show silibinin promotes destruction of cells damaged by UVA, but not healthy cells. According to senior study author Rajesh Agarwal, “When you have a cell affected by UV radiation, you either want to repair it or kill it so that it cannot go on to cause cancer. We show that silibinin does both.”
Although a great deal more research will be needed before dermatologists suggest milk thistle supplementation for their patients to ward off skin cancer, the evidence is compelling. The traditional approach for protecting the skin (avoiding the hot sun, covering exposed skin, wearing sunscreen) is vital to preserving the skin’s vitality. But silibinin seems to add another safeguard. Likely to become the focus of future dermatological study, silibinin not only protects and helps in the repair of liver cells – it also appears to offer a similar type of protective and reparative assistance to skin cells.
Milk Thistle Extract Fights Cushing Disease Brain Tumor, Research Finds
- By James Ayre
Milk thistle extract (silbinin) works effectively to alleviate symptoms of Cushing Disease (caused by a tumor in the pituitary gland in the brain), according to new comprehensive research from the Max Planck Institute. The research included work done using cell cultures, animal models, and also human tumor tissue.
The treatment appears to be so effective that the researchers involved in this work think that it may allow some patients to avoid brain surgery completely — an ideal outcome as far as treatment of Cushing Disease (which is not Cushing’s Syndrome it should be noted) goes.
In Cushing Disease, a brain tumor in the pituitary gland causes the secretion of increased levels of the stress hormone adrenocorticotropin (ACTH), which triggers the release of the stress hormone cortisol from the adrenal glands — which leads to fat gain, muscular weakness, elevated blood pressure, and diminished testosterone levels, amongst other things.
Patients with the disease are highly prone to microbial infections, depression, osteoporosis, and may show cognitive deficiencies. Standard treatment for severe case currently is brain surgery — which in 80-85% of cases results in the tumor being removed. Inoperable cases exist though — and as it stands are treated with a regimen that is accompanied by severe side effects.
Effective treatment via simpler, cheaper, and safer, compounds such as silbinin (milk thistle extract) would be of great use.
“Silibinin is the major active constituent of milk thistle seeds. It has an outstanding safety profile in humans and is already used for the treatment of liver disease and poisoning,” stated Marcelo Paez-Pereda, lead researcher behind the new study. (See: Milk Thistle (Silybum marianum) Benefits, Side Effects, & Silymarin Uses + Research Findings)
The research found that with silibinin treatment, tumour cells reverted to normal ACTH production, tumor growth slowed down considerably, and “symptoms of Cushing Disease disappeared in mice”.
A recent press release provides further information:
- In 2013, the Max Planck scientists filed a patent on a broad family of chemical and natural compounds, including silibinin, to treat :pituitary tumours. Compared to humans, of which only 5.5 in 100,000 people worldwide develop Cushing Disease, this condition is very common :in several pets. For example, 4 % of dogs and even 7 % of horses suffer from Cushing Disease. Thus, the researchers now plan to test special formulations with a very pure substance and slow release of the active component silibinin in clinical trials.
- In their first experiments the researchers found tremendously high amounts of the heat shock protein 90 (HSP90) in tumour tissue from patients with Cushing Disease. In normal amounts HSP90 helps to correctly fold another protein, the glucocorticoid receptor which in turn inhibits the production of ACTH.
“We knew that Cushing Disease is caused by the release of too much ACTH. So we asked ourselves what causes this over production and how to stop it.”
“As there are too many HSP90 molecules in the tumor tissue, they stick to the glucocorticoid receptor,” explained Paez-Pereda. “We found that silibinin binds to HSP90 thus allowing glucocorticoid receptor molecules to dissolve from HSP90. With silibinin we might have discovered a non-invasive treatment strategy not only for the rare Cushing Disease but also for other conditions with the involvement of glucocorticoid receptors such as lung tumors, acute lymphoblastic leukemia or multiple myeloma.” The new findings are detailed in a paper published in the journal Nature Medicine.
Did You Know? Surprising Benefit of Milk Thistle
- (Editors at LiverSupport.com)
A growing body of research is demonstrating that silymarin can help decrease blood sugar levels in those with diabetes and those with insulin resistance – a precursor to diabetes. Researchers hypothesize this is because of milk thistle’s ability to support and improve liver function. The liver plays a role in producing and regulating hormones. Insulin is a hormone and when released into the bloodstream, it lowers blood sugar levels.